Entry Nos. 1800–1899

1831

#1851

Recherches sur quelques combinaisons du chlore.

Soubeiran, like Liebig and Guthrie, discovered chloroform; it is difficult to determine who was first, as each may have allowed an interval of time to elapse between discovery and publication.

1832

#1852

Ueber die Verbindungen, welche durch die Einwirkung des Chlors auf Alkohol, Aether, ölbildenes Gas und Essiggeist entstehen.

Discovery, in 1831, of chloroform and chloral. Independently chloroform was discovered by Souberian and by Guthrie.

1832

#1853

Nouvelles observations sur les principaux produits de l’opium.

Isolation of codeine.

1833

#1854

Ueber die Darstellung des Atropins in weissen Krystallen.

Mein isolated atropine in pure form in 1831. Digital facsimile from Google Books at this link.

1834

#1855

Ueber einige Producte der Steinkohlendestillation.

Carbolic acid first prepared from coal-tar.

1839 –1840

#1856

The elements of materia medica, comprehending the natural history, preparation, properties, composition, effects and uses of medicines. 2 vols.

The first great English work on the subject, widely published and used in England and America. Pereira was Professor of Materia Medica at the School of Pharmacy set up by the Pharmaceutical Society of Great Britain. D…

1839

#1857

Recherches sur la salicine et les produits qui en dérivent.

Piria made salicylic acid from salicin.

1841

#1858

Treatise on the oleum jecoris aselli, or cod liver oil.

Bennett visited Paris and Germany, and learned there of the beneficial effects of cod liver oil. His book drew the attention of English medical men to the value of the oil.

1844

#1859

Mémoire sur l’alcool amylique.

Discovery of amyl nitrite.

1845

#1860

Mémoire sur la digitale pourprée.

Isolation of an active principle in digitalis, amorphous digitalin, more potent than the plant itself.

1848

#1861

Vorläufige Notiz über eine neue organische Base im Opium.

Isolation of papaverine.

1857

#1863

Leçons sur les effets des substances toxiques et médicamenteuses.

Bernard included a summary of his experiments with curare in the Leçons to establish his priority in researching its effects. He demonstrated in these experiments the susceptibility of the nerve-muscle preparation to …

1860

#1864

Du coaltar saponiné, désinfectant énergique, arrètant les fermentations, de ses applications a l'hygiène, la thérapeutique, a l'histoire naturelle.

Lemaire was first to point out the antiseptic properties of carbolic acid. Digital facsimile from BnF Gallica at this link.

1860

#1865

Ueber eine neue organische Base in den Cocablättern.

Isolation of cocaine, 1859, from the coca leaf, brought from Peru by Scherzer.

1864

#1866

British pharmacopoeia, published under the direction of the General Council of Medical Education and Registration of the United Kingdom, pursuant to the Medical Act, 1858.

PHARMACOPOEIA

First official British pharmacopoeia.

1868 –1869

#1867

On the connection between chemical constitution and physiological action.

Brown and Fraser were the first to investigate the relationship between the chemical constitution of substances and their action upon the body. "Although Crum Brown apparently never contemplated the practice of medici…

1868

#1868

Recherches chimiques et physiologiques sur l’erythroxylum coca du Pérou et la cocaïne.

The author, formerly a surgeon in the Peruvian army, issued the first study of the pharmacological action of cocaine, containing the earliest suggestion of its use as a local anesthetic. Leclerc issued the commercial …

1869

#1869

Das Chloral, ein neues Hypnoticum.

Demonstration of the value of chloral hydrate as a hypnotic. See also his monograph Das Chloralhydrat, Berlin, 1869.

1880

#1870

Medicinal plants, being descriptions with original figures of the principal plants employed in medicine. 4 vols.

1880

#1871

Ueber die physiologische Wirking des Cocaïn.

Anrep studied the action of cocaine and, like Moréno y Maïz, suggested that it might be used as a local anesthetic.

1881

#1873

Die natürlich vorkommenden mydriatisch wirkenden Alkaloïde.

Isolation of hysocine (scopolamine), an anti-nausea drug.

1883

#1874

The extra pharmacopoeia of unofficial drugs … With references to their use abstracted from the medical journals by W. Wynn Westcott.

29th edition, 1989.

1883

#1875

Grundriss der Arzneimittellehre.

Schmiedeberg, leading German pharmacologist, was professor at Dorpat and Strasburg. Among his many valuable investigations may be mentioned his study of the effect of drugs on the circulation.

1884

#1877

Recherches cliniques et physiologiques sur la paraldéhyde.

Introduction of paraldehyde into therapeutics as a narcotic.

1884

#1878

Ueber das Antipyrin, ein neues Antipyreticum.

Introduction of antipyrine.

1884

#1879

Eine neue Form medicamentöser Einverleibung.

Unna introduced specially coated pills for local absorption in the intestine.

1884 –1886

#1880

Vorlesungen über Pharmakologie.

Includes his test for quinine in urine. English translation of second edition, 1895-97. Binz was Professor of Pharmacology at Bonn. His most important work was perhaps the demonstration that quinine in low concentrati…

1885

#1881

A text-book of pharmacology, therapeutics and materia medica.

Brunton was physician to St. Bartholomew’s Hospital and an eminent pharmacologist. He is notable for his introduction of amyl nitrite in the treatment of angina pectoris and for a vast amount of other work concerning …

1886

#1882

Ueber Disulfone.

Preparation of sulphonal.

1886

#1883

Ichthyol und Resorcin als Repräsentanten der Gruppe reduzierender Heilmittel.

Unna introduced ichthyol and resorcinol into medicine. Supplement to Mh. prakt. Derm., No. 1.

1888

#1884

Sulfonal, ein neues Schlafmittel.

Introduction of sulphonal, previously discovered by Baumann.

1890

#1885

Strophanthus hispidus; its natural history, chemistry, and pharmacology.

Introduction of Strophanthus hispidus.

1894

#1886

The physiological action of the nitrites of the paraffin series, considered in connection with their chemical constitution.

1894 –1895

#1887

The chemistry of ipecacuanha.

Emetine first obtained in pure form.

1895

#1888

Neue Synthese der Harnsäure und ihrer Methylderivate.

1896

#1889

Ueber das Pyramidon, ein Antipyrinderivat.

Filehne was responsible for the introduction of amindopyrine (pyramidon).

1897

#1890

Die chemischen Grundlagen der Lehre von der Giftwirkung und Desinfection.

Krönig and Paul described a new method for the quantitative study of disinfection and laid the foundation of modern knowledge of disinfectants.

1899

#1891

Pharmakologisches über Aspirin (Acetylsalicylsäure).

Acetylsalicylic acid (aspirin) introduced into medicine.

1903

#1892

Ueber eine neue Klasse von Schlafmitteln.

Synthesis of barbitone (Barbitol), the first available barbiturate.

1903

#1893

Standardisation of disinfectants.

Rideal–Walker method for testing disinfectants.

1905

#1894

Physiological and pharmacological studies of magnesium salts.

A study of the anesthetic and other effects of magnesium salts.

1906

#1895

An active alkaloid from ergot.

Isolation of ergotoxine. With F. H. Carr.

1909

#1896

On the pharmacological action of some phthaleins and their derivatives.

This work led to the universal clinical use of phenolsulphonephthalein in renal function tests and of phenoltetrachlorphthalein in hepatic function tests.

1909

#1897

On the relation between the toxicity and chemical constitution of a number of derivatives of choline and analogous compounds.

1910

#1898

Chemical structure and sympathomimetic action of amines.

Discovery of histamine in an ergot extract.

1910

#1899

The physiological action of β-iminoazolylethylamine.

Study of the effect of histamine.

1854

#10130

On the medicinal and toxicological properties of the cryptogamic plants of the United States.

Separate edition: New York: Baker, Godwin & Co, 1854. Digital facsimile from Google Books at this link.