Entry Nos. 3000–3099

1556

#3049

Curationum medicinalium centuriae quatuor.

Contains (Cent. iii, curat. 70, p. 286) first recorded case of purpura as a separate entity, not associated with fever. English translation of this section in Major, Classic descriptions of disease, 3rd. ed., 1945, p.…

1652

#3050

Iatrologismorum seu medicinalium observationum pentecostae quinque utilibus praeceptis.

Panaroli described hemolytic jaundice of the newborn.

1735

#3051

Epistolica dissertatio altera pro spicilegio observationum de morbo maculoso haemorrhagico et noxiis nonnulis mytulis perscripta.

Behrens gave the name “morbus maculosus haemorrhagicus” to the disease purpura haemorrhagica. His paper is reprinted in Werlhof’s Opera medica, Hannover, 1775, 2,615-36.

1735

#3052

Disquisitio medica et philologica de variolis et anthracibus.

Werlhof gave a classic description of purpura haemorrhagica (“Werlhof’s disease”).

1803

#3054

An account of an haemorrhagic disposition existing in certain families.

Otto recognized and adequately described hemophilia, noting that females are not affected but may transmit the disease. His paper is one of the first great contributions to medicine in North America. Reproduced in Maj…

1811

#3055

Observations on the surgical anatomy of the head and neck.

Burns was the first to suggest (p. 31) ligature of the innominate artery. His book describes “Burns’s space”, the fascial space at the suprasternal notch. The first recorded case of chloroma (myeloid sarcoma, granuloc…

1820

#3056

Von einer erblichen Neigung zu tödtlichen Blutungen.

In his description of hemophilia Nasse stressed the immunity of females, despite their ability to transmit the disease. This fact has become known as “Nasse’s law”.

1823

#3057

Observations sur l’état des veines dans les infiltrations des membres.

Description of venous obstruction and edema.

1837

#3058

Peliosis rheumatica. In his Allgemeine und specielle Pathologie und Therapie, 2, 48-49.

“Schönlein’s disease” (purpura) first described. English translation in No. 2241.

1843

#3059

Experimental and practical researches on inflammation and on the origin and nature of tubercles of the lungs.

Addison made important observations on the blood corpuscles. He is by some considered “the world’s first hematologist”. He gave the first description of leucocytosis, so named by Virchow in 1858, and he anticipated Co…

1843

#3060

Essai d’hématologie pathologique.

The first monograph on hematology in its "modern" sense. Andral established analysis of the blood on the basis of exact knowledge of the blood components. He analysed the blood fibrin and albumin. He recognized severa…

1845

#3061

Case of hypertrophy of the spleen and liver, in which death took place from suppuration of the blood.

First definite description of leukemia as a blood disorder; a case under the care of Sir R. Christison but reported by Bennett. On p. 400 of the same journal is a report of a case by D. Craigie, referring to a patient…

1845

#3062

Weisses Blut.

Only six weeks after Bennett, Virchow independently published a report on the necropsy of a case of leukemia. He gave the condition its present name. For translation, see Major, Classic descriptions of disease, 3rd. e…

1855

#3063

Die Haemophilie oder die Bluterkrankheit.

First full clinical description of hemophilia.

1856

#3064

Ueber farblose Blutkörperchen und Leukämie. In his Gesammelte Abhandlungen zur wissenschaftlichen Medicin, pp. 147-218.

Includes his paper on “weisses Blut” (see No. 3062) and three later papers on leukemia. See No. 3006.

1868

#3065

Über den Zusammenhang von Purpura und Intestinalstörungen.

“Henoch’s purpura”. Henoch described a form of purpura with abdominal symptoms first mentioned by Heberden (No. 3053). See also the same journal, 1874, 11,622, 641-43. This paper is translated into English in No. 2241.

1870

#3066

Ein Fall von Leukämie mit Erkrankung des Knochenmarkes.

Neumann was the first to note changes in the bone marrow in leukemia, and he proposed the term “myelogenous leukemia”.

1875

#3067

Ueber das Vorkommen von Bilirubinkrystallen bei neugebornen Kindern.

Kernicterus first described.

1887

#3068

Ueber Purpura fulminans.

First description.

1890

#3069

Die Gelenkerkrankungen bei Blutern mit Berücksichtigung der Diagnose.

König gave a detailed description of joint involvement in hemophilia.

1892

#3070

Sur une forme spéciale de cyanose s’accompagnant d’hyperglobulie excessive et persistante.

Vaquez first described polycythemia vera (erythremia). Osler’s paper on the subject (No. 3073) made it generally known in the English-speaking world, and the condition has since been named “Vaquez–Osler disease”. For …

1899

#3071

A new preparation for rapidly fixing and staining blood.

Jenner’s methylene blue-eosin stain for blood.

1901

#3072

A fatal case of acute primary infectious pharyngitis.

First recorded case of extreme leucopenia.

1903

#3073

Chronic cyanosis, with polycythaemia and enlarged spleen: a new clinical entity.

When describing polycythemia with cyanosis, Osler thought it a new entity, but later acknowledged the priority of Vaquez’s description (No. 3070). Reprinted in Med. Classics, 1939, 4,254-75.

1903

#3074

Ueber eine Methode zur Untersuchung des lebenden Knochenmarks von Thieren und über das Bewegungsvermögen der Myelocyten.

Wolff-Eisner trephined the tibia and femur of experimental animals and suggested biopsy of bone marrow as a clinical procedure.

1904

#3075

Die neutrophilen weissen Blutkörperchen bei Infektions-Krankheiten.

“Arneth count”. Arneth distinguished five groups of polymorphonuclear leucocytes and advocated the estimation of these groups as a valuable aid in the determination of bone-marrow reaction to infective and other agent…

1905

#3076

Die Bedeutung der Blutdruckmessung für die Praxis.

Includes (p. 396) description of “Geisböck’s disease” – polycythemia hypertonica.

1905

#3077

Pathologie der Primärerkrankungen des lymphatischen und hämatopoetischen Apparates.

Includes (p. 151) Sternberg’s description of lymphogranulomatosis, which was given the eponym “Sternberg’s disease”.

1907 –1908

#3078

Blutkrankheiten und Blutdiagnostik.

1907

#3079

Septische Erkrankungen bei Verkümmerung des Granulozytensystems.

First reported case of complete agranulocytosis.

1908

#3080

Per la patogenesi e per la diagnosi delle malattie del sangue e degli organi emopoietici. Puntura esplorativa del midollo osseo.

Introduction of bone marrow biopsy by puncturing the shaft of the tibia.

1911

#3081

Haemophilia.

Bulloch and Fildes, in their detailed account of hemophilia, claimed to have established immunity to the disease in females, and denied the authenticity of published cases of female hemophilia. They confirmed the law …

1911

#3082

Grundriss der hämatologischen Diagnostik.

One of the leaders in modern hematology, Pappenheim improved the methods of staining blood cells.

1915

#3083

Die essentielle Thrombopenie (konstitutionelle Purpura-Pseudo-Hämophilie).

Frank’s essential thrombopenia.

1918

#3084

Zur Therapie der Polyzythämie.

Phenylhydrazine hydrochloride first used in the treatment of polycythemia.

1921

#3085

Studies of the suspension stability of the blood in pulmonary tuberculosis.

Westergren’s method of measuring the erythrocyte sedimentation rate.

1922

#3086

Gangräneszierende Prozesse und Defekt des Granulocytensystems.

“Schultz’s syndrome” – first description of agranulocytic angina. Schultz reported four cases of necrotic ulcerative infection of the throat with complete or almost complete disappearance of polymorphonuclears. To des…

1923

#3087

Die Sternumtrepanation, ein einfache Methode zur diagnostischen Entnahme von Knochenmark bei Lebenden.

Bone marrow biopsy by sternal puncture.

1927

#3088

"Methodology of examining bone marrow in live patients, with haemopoietic disease."

Needle puncture of bone marrow biopsy. (In Russian.) German account in Folia haemat. (Lpz.), 1929, 38, 233-40. English translation from the German in Bick, Classics of orthopaedics, 339-44.

1928

#3089

Demonstratie van een paar zeldzaam voorkomende typen van bloedlichaampjes en bespreking der patiënten.

See No. 3092.

1929

#3090

The velocity of blood flow in health and disease as measured by the effect of histamine on the minute vessels.

Measurement of circulation time.

1931

#3091

Eine klinisch brauchbare Bestimmungsmethode der Blutumlaufszeit mittels Decholininjektion.

The decholin method for estimation of circulation time. With J. Deutsch and Z. Brull.

1931

#3092

Over een familiaire anomalie der leucocyten.

Pelger–Huët anomaly of the nuclei of the leucocytes; see also No. 3089. German translation in Klin. Wschr., 1932, 11,1264-66.

1934

#3093

The haemostatic possibilities of snake-venom.

Snake venom used in the treatment of hemophilia.

1934

#3094

Sternal puncture; preliminary note.

Needle for sternal puncture.

1935

#3095

The prothrombin in hemophilia and in obstructive jaundice.

Quick’s method for determination of prothrombin clotting time. See also Amer. J. med. Sci.,1935, 190,501-11.

1935

#3096

A standardized technique for the blood sedimentation test.

Wintrobe’s method for the determination of the erythrocyte sedimentation rate.

1938

#3097

The use of vitamin K and bile in treatment of the haemorrhagic diathesis in cases of jaundice.

Vitamin K used in the treatment of hemorrhagic disease.

1939

#3098

Studies on leukemia with the aid of radioactive phosphorus.

Therapeutic use of radioactive isotopes for the treatment of leukemia. John H. Lawrence was the brother of Ernest Orlando Lawrence, inventor of the cyclotron; John Lawrence also worked at the Lawrence Berkeley Nationa…

1940

#3099

Nuclear physics and therapy: preliminary report on a new method for the treatment of leukemia and polycythemia.

Radio-phosphorus in treatment of leukemia.