Latest Entries
Recently added and updated annotations in the corpus.
1930
#14322
Les femmes et la progrès des sciences médicales.
1867 –1872
#14321
Arsenal de la chirurgie contemporaine. Description, mode d'emploi et appréciation des appareils et instruments en usage pour le diagnostic et le traitement des maladies chirurgicales, l'orthopédie, la prothèse, les opérations simples, générales, spéciales et obstétricales. 2 vols.
Digital facsimile from Google Books at this link.
1882
#14320
Chirurgie de la main.
The first manual on hand surgery. Digital facsimile from wellcomecollection.org at this link.
2024
#14319
Exposed: The hidden history of the pelvic exam.
2021
#14318
Coming home: How midwives changed birth.
1946
#14317
Radioactive Element 94 from deuterons on uranium.
"This letter was received for publication on the date indicated (January 28, 1941), but was voluntarily withheld from publication until the end of the war." Seaborg and McMillan discovered element 94, which they named…
1835
#14316
On the osteology of the chimpanzee and orang utan.
Owen was the first anatomist, after Petrus Camper, to distinguish decisively between the chimpanzee and the orangutan. He began studying the anatomy of non-human primates in the 1830s, when the Regent’s Park Zoo in Lo…
1974
#14315
"Conformational Coupling in Biological Energy Transductions." In L. Ernster et al. (eds.), Dynamics of Energy-Transducing Membranes, pp. 289-301.
In 1997 Boyer shared the Nobel Prize in Chemistry with John Walker and Jens C. Skou “for their elucidation of the enzymatic mechanism underlying the synthesis of adenosine triphosphate (ATP).” The Nobel Prize committe…
1994
#14314
Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria.
Walker used X-ray crystallography to determine the structure of ATP synthase (ATPase or adenosine triphosphatase). In 1997 Walker shared the Nobel Prize in Chemistry with Paul Boyer and Jens C. Skou “for their elucida…
1926
#14313
Studies in intracranial physiology & surgery. The third circulation. The hypophysis. The gliomas. The Cameron Prize Lectures delivered at the University of Edinburgh October 19, 20, 22, 1925.
This series of three lectures was an analytical review by Cushing of the three main categories of scientific work that he had accomplished during the previous 25 years. Remarkably, Cushing completed this review and de…
1955
#14312
The maser - new type of microwave amplifier, frequency standard, and spectrometer.
In 1964 Townes shared the Nobel Prize in Physics with Nicolay Gennadiyevich Basov and Alexandr Mihailovich Prokhorov "for fundamental work in the field of quantum electronics, which has led to the construction of osci…
1965
#14311
Enzymatic basis for the active transport of sodium and potassium across the cell membrane.
Skou discovered that the active transport of sodium and potassium is carried out in the cell membrane by an enzyme that serves as a sodium and potassium "pump," that catalyzes ATP hydrolysis. He named the enzyme "sodi…
1895
#14310
Argon, a new constituent of the atmosphere.
Discovery of argon, the first discovery of an inert gas. In 1904 Ramsay was awarded the Nobel Prize in Chemistry "in recognition of his services in the discovery of the inert gaseous elements in air, and his determina…
1896
#14309
Centenaire de la faculté de médecine de Paris (1794-1894).
Digital facsimile from Google Books at this link.
1897
#14308
De Vrouw: Haar bouw en haar inwendige organen. Een populaire schets.
Jacobs was the first woman in the Netherlands to graduate from medical school. In 1882 she founded the first birth control clinic in the Netherlands and "the first clinic in the world devoted solely to dissemtinating …
2012
#14307
Corps du papier. L'Anatomie en papier mâché du Docteur Auzoux. Text: Christophe Degueurce. Photos: Didier Gaillard. Préface: Philippe Comar.
Outstanding color photographs.
1960
#14306
The sequence of the amino acid residues in performic acid-oxidized ribonuclease.
In 1959 Moore and Stein announced the first determination of the complete amino acid sequence of an enzyme, ribonuclease. In 1972 Moore and Stein shared half of the Nobel Prize in Chemistry with Christian B. Anfinsen …
1963
#14305
The genetic control of tertiary protein structure studies with mode systems.
In 1972 Anfinsen shared half of the Nobel Prize in Chemistry with Stanford Moore and William H. Stein for "for his work on ribonuclease, especially concerning the connection between the amino acid sequence and biologi…
1971
#14304
Oral or nasogastric maintenance therapy in pediatric cholera patients.
1968
#14303
Oral maintenance therapy for cholera in adults.
Abstract: "An oral solution containing glucose, sodium chloride, sodium bicarbonate, and potassium chloride or citrate was used as maintenance therapy for acute cholera. In comparison with control patients who receive…
2000
#14302
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA.
Working with the let-7 gene, the authors led by Ruvkun showed that microRNA encoded by the let-7 gene was highly conserved, and present throughout the animal kingdom, proving that gene regulation by microRNA is univer…
1993
#14301
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans.
The authors cloned and generated the sequence of the lin-14 gene. They discovered that a segment in lin-14 mRNA (messenger RNA), was necessary for its inhibition by lin-4. Ruvkun and Ambros (No. 14010) then compared r…
2003
#14300
Design of a novel globular protein fold with atomic-level accuracy.
Called, "the breakthrough in computational de novo protein design." This was the proof of concept paper that computers and AI could be used to predict protein structures accurately and much faster than with convention…
1889
#14299
Die Haut Arterien des menschlichen Körpers.
Manchot was the first to describe the vascular territories of the human skin. This work was translated into English by J. Ristic with an introduction by William D. Morain as The cutaneous arteries of the human body (N…
1971
#14298
Marijuana reconsidered.
A cultural classic on the understanding of the marijuana experience, and reform of prohibitions against marijuana use by a professor of psychiatry at Harvard Medical School. Besides describing marijuana's psychologica…
2004
#14297
The detection of Monkeypox in humans in the Western Hemisphere.
The first report on detection of Mpox (Monkeypox) in humans in the Western Hemisphere, elaborating and expanding on cases reported in 2003 in Wisconsin and Milwaukee. These patients had been bitten by prairie dogs. At…
1972
#14296
A human infection caused by monkeypox virus in Basankusu Territory, Democratic Republic of Congo.
Reports the first described case of Mpox in humans. It was thought that acquisition occurred through zoonotic contact. Order of authorship in the original paper: Ladnyj, Ziegler, Kima. (Thanks to Juan Weiss for this r…
1879
#14295
Fasting girls: their physiology and pathology.
Digital facsimile from Google Books at this link.
2008
#14294
In vivo imaging of membraine-associated glycans in developing Zebrafish.
The authors applied click chemistry to previously inaccessible biologic environments. Towards that end, they used a modified azide and clicking it onto an alkyne but without using copper ions which are toxic to cells,…
2000
#14293
Cell surface engineering by a modified Staudinger reaction.
In 2022 Carolyn Bertozzi shared the Nobel Prize in Chemistry with Barry Sharpless and Morten Meldal for discovery of click chemistry. Bertozzi invented a biorthogonal variation of Sharpless and Meldal reactions. In th…
2002
#14292
Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides.
In 2022 Morten Meldal shared the Nobel Prize in Chemistry with Carolyn Bertozzi and Barry Sharpless for the discovery of click chemistry. Simultaneously, but independently of Sharpless, the authors discovered that cop…
2001
#14291
Click chemistry: Diverse chemical function from a few good reactions.
In 2022 Barry Sharpless shared the Nobel Prize in Chemistry with Carolyn Bertozzi and Morten Meldal for "the discovery of click chemistry." "Barry Sharpless coined the concept of click chemistry, where molecular build…
1953
#14290
Switching systems as mechanized brains.
Written in the earliest days of automatic switching systems when few electronic computers existed, Meszar's paper raised the question of whether certain aspects of human thought are computable and others are not. Mesz…
1949
#14289
The mind of mechanical man.
Jefferson’s paper on the differences between electronic computers and the human brain inspired Alan Turing to respond with his famous paper, “Computing machinery and intelligence” (1950), which introduced the “Turing …
2002
#14288
An introduction to human evolutionary anatomy.
1924
#14287
The morphology and evolution of the apes and man. With a foreward by Professor G. Elliot Smith.
As far as I able to determine in 2024, Sonntag's book was the first attempt to write a general treatise on what eventually came to be called "human evolutionary anatomy," in the sense of studying the relationship betw…
1936
#14286
Age and other factors in motor recovery from precentral lesions in monkeys.
This was the first of a series of papers by Kennard that led to what became known as the Kennard Principle, which posits a negative linear relationship between age of a brain lesion and the recovery outcome. The earli…
1827
#14285
Der Leichnam des Menschen in seinen physischen Verwandlungen nach Beobachtungen und Versuchen.
The human corpse in its physical transformations according to observations and experiments.
1945
#14284
Acetylation of sulfanilamide by liver homogenates and extracts.
Discovery of co-enzyme A and its importance for intermediary metabolism. This discovery illuminated “the process by which cells make available the energy to drive their manufacturing processes” (Judson, p. 245). In 19…
1960
#14283
Structure of haemoglobin: A three-dimensional Fourier synthesis at 5.5-A. resolution, obtained by X-ray analysis.
Solution of the structure of hemoglobin, a protein with 10,000 atoms. This was the culmination of 30 years of research by Perutz. Order of authorship in the original paper: Perutz, Rossmann, Culis, Muirhead, Will, Nor…
1942
#14282
Purification of penicillin.
Abraham and Chain first announced the purification of penicillin, a critical step before production of the drug could begin, in a two paragraph paper published on a single page of Nature on March 21, 1942. The method,…
1961
#14281
Fate of tritiated noradrenaline at the sympathetic nerve endings.
Using electron microscopy and tritiated norepinephrine, the authors discovered the area in the nerve endings in which the catecholamines were concentrated, and also observed enhanced radioactive catecholamine release …
1933
#14280
Synthesis of ascorbic acid.
Haworth and Hirst successfully synthesized vitamin C in the laboratory. This was the first vitamin to be artificially produced. Their breakthrough made it possible for vitamin C, or ascorbic acid as Haworth called it,…
1938
#14279
The application of isotopic indicators in biological research.
A summary of Hevesy's research on the topic for which he received the 1943 Nobel Prize in Chemistry. (Thanks to Juan Weiss for this reference.)
1884
#14278
Recherches sur la conductibilité galvanique des electrolytes. 1 & 2.
Arrhenius first published the theory of electrolytic dissociation in his doctoral thesis of 1884. In 1903 he received the Nobel Prize in chemistry "in recognition of the extraordinary services he has rendered to the a…
1950
#14277
The interconversion of the retinenes and vitamins A in vitro.
Continuing his research on retinal pigments structure and function with emphais on rhodopsin, Wald deciphered the interconversion of rhodopsin to retinene to Vitamin A. (Thanks to Juan Weiss for this reference and its…
1945 –1946
#14276
The chemical evolution of vision.
In this paper Wald identified structures for all the visual pigments and their peak absorption wavelengths. He detailed the function of the rods and cones and broke down visual photonic perception at the molecular lev…
2010
#14275
Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels.
Patapoutian and colleagues characterized the PIEZO1, PIEZO2, and TRPM8 receptors that detect pressure, menthol, and temperature. With Mathur, J.; Schmidt, M.; Earley, T. J.; Ranade, S.; Petrus, M. J.; Dubin, A. E. See…
1997
#14274
The capsaicin receptor: a heat-activated ion channel in the pain pathway.
"Abstract: Capsaicin, the main pungent ingredient in ‘hot’ chilli peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central ner…
2001
#14273
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.
Kaelin and colleagues identified aspects of the molecular machinery in Von Hippel-Landau disease that regulates the activity of genes in response to varying levels of oxygen. In 2019 Kaelin shared the Nobel Prize in P…