Facets

1490

#47

Liber Teisir, sive rectificatio medicationis et regiminis. Antidotarium. Translated from Arabic into Hebrew by Jacobus Hebraeus; into Latin by Paravicius. Add: Averroes: Colliget.

This is a Latin translation from a Hebrew version dating from 1280. Avenzoar, the greatest Muslim physician of the Western Caliphate, described the itch-mite, Sarcoptes scabiei, serous pericarditis, mediastinal absces…

1684

#1311

Dr. Willis's practice of physick.

The only complete edition of Willis's works in English, translated by the poet Samuel Pordage. It contains the translations of all his works except his Affectionum quae dicuntur hystericae (1671). The collection inclu…

1761

#2607.1

Cautions against the immoderate use of snuff. Founded on the known qualities of the tobacco Plant; and the effects it must produce when this way taken Into the body: And by instances of persons who have perished miserably of diseases, occasioned, or rendered incurable by its use,

First clinical report (pp. 30-31) of an association between tobacco and cancer, in this case “polypusses” of the nose caused by taking snuff. Hill was a distinguished botanist and apothecary, although regarded by some…

1795

#2609.1

De morbis vasorum absorbentium corporis humani.

Soemmerring noted an association between pipe smoking and cancer of the lip (p. 109).

1818

#10069

Oeuvres complètes de Bordeu, précédés d'une notice sur sa vie et sur ses ouvrages, par M. le Chevalier Richerand. 2 vols.

1820

#2073

Pharmacologia; or the history of medicinal substances, with a view to establish the art of prescribing. 3rd ed.

First description of cancer caused by arsenic (p. 133).

1867

#1996.3

On the electrolytic treatment of tumors, and other surgical diseases.

Althaus introduced Duchenne’s methods into England. He was the first to employ electrolysis for medical purposes. Greatly expanded third edition, 1873.

1878

#4075.1

On the treatment of psoriasis by an ointment of chrysophanic acid.

Introduction of chrysarobin in dermatology.

1886

#1883

Ichthyol und Resorcin als Repräsentanten der Gruppe reduzierender Heilmittel.

Unna introduced ichthyol and resorcinol into medicine. Supplement to Mh. prakt. Derm., No. 1.

1894

#2107

Contribution à l’étude du vénin des serpents.

Calmette carried out extensive investigations on the immunization of animals to venoms. He obtained antivenom sera with therapeutic properties.

1895

#2108

On the rendering of animals immune against the venom of the cobra and other serpents; and on the antidotal properties of the blood serum of the immunised animals.

Fraser investigated the possibilities of immunization against cobra venom and obtained “antivenene”, an antivenom serum.

1897

#2002

Demonstration eines mit Röntgenstrahlen behandelten Falles von Naevus pigmentosus pilosus.

First use of x rays for deep irradiation therapy.

1898

#2003

Sur une substance nouvelle radio-active, contenue dans la pechblende.

The Curies, studying the radioactivity of minerals containing uranium and thorium, isolated from pitchblend a substance which they called radium and which they showed to possess an astonishing degree of radioactivity.…

1902

#2590

De l’action anaphylactique de certains venins.

First full description of the phenomenon of “anaphylaxis,” the name of which was coined by Richet. Abbreviated English translation in Bibel, Milestones of immunology (1988). In 1913, Richet was awarded the Nobel Prize…

1903

#2112

Zur Kenntniss der Cobragift activirenden Substanzen.

English translation in Ehrlich, Studies in immunity, 1910.

1903

#2113

Ueber die Isolirung von Schlangengift-Lecithiden.

English translation in Ehrlich, Studies in immunity, 1910.

1904

#2437

The constituents of chaulmoogra seeds.

Hydnocarpus wightiana or Chaulmoogra is a tree in the Achariaceae family. The oil from seeds of Hydnocarpus wightiana or Chaulmoogra, a tree in the Achariaceae family, was widely used in Indian medicine and Chinese tr…

1906

#2005

Interprétation de quelques résultats de la radiothérapie et essai de fixation d’une technique rationelle.

Bergonié-Tribondeau law, “the sensitivity of cells to radiation varies directly with the reproductive capacity of the cells and inversely with their degree of differentiation” (Dorland).

1916

#2643

Ueber die künstliche Erzeugung von Karzinom.

First experimental production of tar cancer in rabbits by painting with tar products. This was the first proof of chemical carcinogenesis.

1924

#2646

The formation of a cancer-producing substance from isoprene (2-methyl-butadiene).

Kennaway produced carcinogenic tars by submitting acetylene or isoprene to high temperatures in an atmosphere of hydrogen, thus proving that some carcinogens are pure hydrocarbons.

1926

#5289

Essai de prophylaxie des trypanosomiases par des dérivés phénylarsiniques administré

First attempt to induce prophylaxis by chemical means in trypanosomiasis. With S. Nicolau and I. Galloway.

1929 –1934

#1125

Die Hormone; ihre Physiologie und Pharmakologie. 2 vols.

1929

#2576.02

Hypersensitiveness to arsphenamine in guinea pigs. I. Experiments in prevention and desensitization.

First demonstration of specific, acquired, lasting refractoriness to sensitization. This is the same or a closely related phenomenon to that demonstrated later by Burnet and Medawar under the name immune tolerance. Se…

1930

#3973

Contribución al estudio sobre la composición quimica de la insulina. Estudio de algunos cuerpos sintéticos solfurados con acción hypoglucemiante.

Discovery of the hypoglycemic effect of certain sulphonamide derivatives. With L. L. Silva and L. Libenson.

1932 –1934

#1921

Handbuch der Chemotherapie. 2 vols.

1932

#2654

The production of cancer by pure hydrocarbons.

Discovery of the carcinogenic properties of dibenzanthracene compounds. With I. Hieger, E. L. Kennaway, and W. V. Mayneord.

1936 –1939

#1172

The physiology and pharmacology of the pituitary body. 2 vols.

Includes an extensive bibliography.

1936

#3974

Protamine insulinate.

Hagedorn created NPH insulin and founded Nordisk Insulinlaboratorium, known today as Novo Nordisk. NPH insulin is one of the earliest examples of engineering drug delivery. Hagedorn became interested in modifying the …

1937

#1925

Action protectrice des éthers phénoliques au cours de l’intoxication histaminique.

First description of structure and action of an antihistamine. In 1957 Bovet was awarded the Nobel Prize in Physiology or Medicine “for his discoveries relating to synthetic compounds that inhibit the action of certai…

1939

#3213

Tabakmissbrauch und Lungencarcinom.

In the first case-control epidemiological study of the effects of tobacco Müller recorded a statistically significant correlation between cigarette smoking and lung cancer. See Alfredo Morabia, "Quality, originality, …

1944

#2659.3

Influence of synthetic oestrogens upon advanced malignant disease.

Administration of synthetic estrogens in advanced mammary cancer caused regression of tumors. With J. M. Watkinson, E. Paterson, and P. C. Koller.

1946

#10133

Nitrogen mustard therapy. Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders.

Widely considered the first uses of chemotherapy for the treatment of malignant diseases.

1948

#2660.1

Temporary remissions in acute leukemia in children produced by folic acid antagonist 4-amethopteroylglutamic acid (aminopterin).

With L. K. Diamond, R. D. Mercer, R. F. Sylvester, and V. A. Wolff.

1949

#3855.1

Imidazoles. IV. The synthesis and antithyroid activity of some 1-substituted-2-mercaptoimidazoles.

Synthesis of methimazole (mercazole, thiamazole), an antithyroid drug more potent than methylthiouracil. With E. C. Kornfeld, K. C. McLaughlin, and R. C. Anderson.

1950

#3215.1

Tobacco smoking as a possible etiologic factor in bronchogenic carcinoma: A study of 684 proved cases.

A case-control study proving an association between heavy prolonged cigarette smoking and bronchogenic carcinoma. See also the following paper on pp. 336-38. Reprinted in J. Amer. med. Assoc. 1985, 253, 2986-97.

1950

#3215.2

Smoking and carcinoma of the lung. Preliminary report.

A study of 1,465 cases of lung cancer and 1,465 matched controls, which confirmed and extended the studies of Wynder and Graham, and others. See also later papers by the same authors in Brit. med. J., 1952, 2,1271-86;…

1952

#7764

Incidence of leukemia in survivors of the atom bomb in Hiroshima and Nagasaki, Japan.

Leukemia was the first cancer to be linked with radiation exposure in atomic bomb survivors.

1953

#2660.4

Aryl-2-halogenoalkylamines. Part XII. Some carboxylic derivatives of NN-Di 2-chloroethylaniline.

Chlorambucil (a nitrogen mustard) used in the chemotherapy of cancer. With J. R. Roberts and W. J. C. Ross.

1954

#2660.7

Cytoactive amino-acid and peptide derivatives. I. Substituted phenylalanines.

Melphalan (a nitrogen mustard) later used in the chemotherapy of cancer.

1955

#2660.8

Carcinolytic action of antibiotics: puromycin and actinomycin.

1956 –1960

#86.4

Collected papers of Paul Ehrlich. Compiled and edited by F. Himmelweit. 3 vols.

Vol. I: Histology, biochemistry, and pathology, Vol. 2: Immunology and cancer research; Vol. 3: Chemotherapy. Most texts are in German. English translations are also published when available. The set includes new Engl…

1956

#1947.3

Mitomycin, a new antibiotic from streptomyces.

Isolation of mitomycin C, effective in Hodgkin’s disease and lymphoma. With six co-authors.

1956

#7782

Preliminary communication: Malignant disease in childhood and diagnostic irradiation in-utero.

Stewart was one of the earliest to study the effect of prenatal X-rays, later replaced by ultrasound. She found that the children of mothers who received these X-rays were almost twice as likely to develop leukemia or…

1957

#3978.3

Pharmacological studies of a new oral hypoglycemic drug.

Phenformin, a biguanide formerly used in diabetes. With L. Freedman and S. L. Shapiro. Clinical report on pp. 193-4.

1958

#2660.11

Neuartige Krebs-Chemotherapeutica aus der Gruppe der zyklischen N-Lost-Phosphamidester.

Cyclophosphamide. With F. Bourseaux and N. Brock.

1958

#4011.1

Experimental ringworm in guinea pigs: oral treatment with griseofulvin.

Use of griseofulvin in the treatment of ringworm.

1963

#2660.14

Evidence that the L-asparaginase of guinea pig serum is responsible for its antilymphoma effects.

1963

#2660.16

The Vinca alkaloids: a new class of oncolytic agents.

Clinical use of vinblastine (for Hodgkin’s disease and other lymphomas) and vincristine (for acute leukemias of childhood). With J. G. Armstrong, M. Gorman, and J. P. Burnett. Preliminary communication in J. Lab. clin…

1964

#7385

Smoking and health: report of the Advisory Committee to the Surgeon General of the Public Health Service.

Definitive 386-page throughly documented study of the carcinogenic and pulmonologic effects of smoking, and the addictive aspects of nicotine. It was published under the supervision of Surgeon-General Luther Terry. Di…

1965

#7790

Mortality from cancer and other causes after radiotherapy for ankylosing spondylitis.