Facets

1969

#2702.4

The rays: a history of radiology in the United States and Canada.

1969

#10611

Computerized mapping of disease and environmental data. A report of the Mapping of Disease (MOD) Project.

This appears to be the earliest monograph on computerized disease mapping. At the time the research was conducted both computer graphics processing and data output in mainframe computers were inadequate for drawing al…

1971

#7405

Histology of the human eye.

Hogan and Alvarado's work was the first book on histology of the eye to include electron microscopy. It also reproduced spectacular three-dimensional representations of ocular ultrastructures by Joan Esperson Weddell.

1971

#10237

Project Gutenberg.

http://www.gutenberg.org/wiki/Main_Page Project Gutenberg, a volunteer project founded in 1971 by Michael S. Hart, was the first digital library. Later leapfrogged by much better financed non-profit or government-spon…

1971

#12601

Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G.

Perlmann (principal investigator) and Engvall conceptualized and developed the very commonly used enzyme-lined immunosorbent assay (ELISA) that uses antibodies to detect proteins and other different immunogens. The as…

1972

#8442

Thesaurus Linguae Graecae: A digital library of Greek literature.

http://stephanus.tlg.uci.edu/tlg.php "The Thesaurus Linguae Graecae (TLG®) is a Special Research Program at the University of California, Irvine. Founded in 1972 the TLG® represents the first effort in the Humanities …

1972

#10505

Medical geography: Techniques and field studies. Ediited by N. D. McGlashan

Chapter 5: "Computers and mapping in medical geography" by R. W. Armstrong appears to be one of the earliest reviews of this subject.

1973

#2700.4

Computerized transverse axial scanning (tomography).

Hounsfield invented computer-assisted tomography (CAT), or computed tomography (CT). In 1979 Hounsfield shared the Nobel Prize in Physiology or Medicine with Allen M. Cormack "for the development of computer assisted …

1973

#2700.5

Image formation by induced local interactions: Examples employing nuclear magnetic resonance.

Lauterbur proposed a workable method for using nuclear magnetic resonance to produce images of tissues. In 2003 Lauterbur shared the Nobel Prize in Physiology or Medicine with Sir Peter Mansfield “for their discoverie…

1973

#257.5

Construction of biologically functional bacterial plasmids in vitro.

Cohen, Boyer and associates developed the first practical method for cloning genes, by the formation of recombinant plasmids which can be used to infect plasmid-free bacteria. The authors demonstrated that if DNA is f…

1974

#6909

Computerized transaxial x-ray tomography of the human body.

Ledley and team developed the developed the ACTA 0100 CT Scanner (Automatic Computerized Traverse Axial)— the first whole-body computed tomography scanner. With G. Di Chiro, A. J. Luessenhop, and H.L. Twigg. For furth…

1974

#7521

Telediagnosis: A new community health resource, Observations on the feasibility of telediagnosis based on 1000 patient transactions.

In 1968 Bird founded and directed the first "telemedicine" system, which linked a medical station at Boston's Logan Airport with doctors at Massachusetts General Hospital, who supplied remote diagnosis, treatment and …

1974

#9487

"A computer-based system for the study and control of drug interactions in hospitalized patients," P. L. Morselli, S. Garattini, and S. N. Cohen, Drug interactions, 363-373.

MEDIPHOR System (Monitoring and Evaluation of Drug Interactions by a Pharmacy-Oriented Reporting System) developed by Cohen, Shortliffe and colleagues at Stanford University Medical School, published as a chapter in t…

1974

#10047

Genome construction between bacterial species in vitro: Replication and expression of staphylococcus plasmid genes in Escherichia coli.

Creation of the first transgenic organism: expression of Staphylococcus aureus genes in Escherichia coli. Digital facsimile from pnas.org at this link.

1974

#10551

The Darwin correspondence project.

http://www.darwinproject.ac.uk/" "Search over 12000 letters and articles..."

1974

#10963

Genome construction between bacterial species in vitro: Replication and expression of staphylococcus plasmid genes in Escherichia coli.

Confirmation of the success of methods outlined in No. 257.5. Abstract: "Genes carried by EcoRI endonuclease-generated fragments of Staphylococcus plasmid DNA have been covalently joined to the E. coli antibiotic-resi…

1975

#7522

Telemedicine: Explorations in the use of telecommunications in health care.

The first book on telemedicine, with contributions by 18 authors, including Kenneth T. Bird. In the final chapter the editors summarize telemedicine programs then operational in the United States. The book also includ…

1975

#9486

A model of inexact reasoning in medicine.

"MYCIN was an early backward chaining expert system that used artificial intelligence to identify bacteria causing severe infections, such as bacteremia and meningitis, and to recommend antibiotics, with the dosage ad…

1975

#14182

Three-dimensional model of purple membrane obtained by electron microscopy.

The invention of Cryogenic electron microscopy (cryo-EM). The novel technique was achieved by "by applying the method to tilted specimens, and using the principles put forward by De Rosier and Klug (GM - 13935), for t…

1976

#7072

The face of madness. Hugh W. Diamond and the origin of psychiatric photography. Edited by Sander L. Gilman.

Papers by Diamond, including their illustrations, edited with an extensive annotated introduction.

1976

#10100

The Watermark. The quarterly publication of Librarians, Archivists and Museum Professionals in the History of the Health Sciences (LAMPHHS).

http://iis-exhibits.library.ucla.edu/alhhs/index.html "Librarians, Archivists, and Museum Professionals in the History of the Health Sciences (LAMPHHS) membership is open to librarians, archivists, and museum professi…

1976

#14222

Correlation of glucose regulation and hemoglobin AIc in diabetes mellitus.

The authors studied 5 diabetic patients and first realized that A1c was an ideal index to reveal the overall control of a patient’s blood sugar over the past several months before a doctor’s visit. They were the first…

1977

#8150

Medical imaging by NMR.

Mansfield developed a mathematical technique that would allow NMR scans to take seconds rather than hours and produce clearer images than the technique Paul Lauterbur developed in 1973. Mansfield showed how gradients …

1977

#10964

Expression in Escherichia coli of a chemically synthesized gene for the hormone somatostatin.

Order of authorship in the original paper: Itakura, Hirose, Crea..., Bolivar, Boyer. Synthesis of the gene for somatostatin (growth hormone-inhibiting hormone (GHIH). This was the first demonstration of a foreign gene…

1977

#11208

Charles Darwin: An annotated bibliographical handlist

This bibliography has been extensively supplemented by the Freeman Bibliographical Database at Darwin Online edited by John van Wyhe. "The database has been supplemented by the entries from unpublished manuscript corr…

1977

#12031

The construction of molecular cloning vehicles. II. A multipurpose cloning system.

Order of authorship in the original publication Bolivar, Rodriguez, Betlach...Boyer...The authors describe the composition and molecular construction of pBR-322 (named after Bolivar and Rodriguez) and call it "the mos…

1978

#567.2

A history of microtechnique: The evolution of the microtome and the development of tissue preparation.

1978

#9720

Recombinant DNA: The untold story.

1978

#12243

Noninvasive assessment of pressure drop in mitral stenosis by Doppler ultrasound.

Order of authorship in the original paper: Hatle, Brubakk, Tromsdal, Angelsen. "Hatle (born 1936) was the pioneer of continuous wave Doppler echocardiography. "Today, Doppler echocardiography is central to our ability…

1978

#13969

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide (tridecamer deoxyribonucleotide/hybridization competitor/hybridon).

Zamecnick and Stephenson reported the first example of specific inhibition of gene expression by an oligonucleotide when they demonstrated that a short oligonucleotide inhibited Rous sarcoma virus replication in cell …

1979

#13929

Transformation of mammalian cells with genes from procaryotes and eucaryotes.

Axel, along with microbiologist Saul J. Silverstein and geneticist Michael H. Wigler, discovered a technique of cotransformation via transfection. This process, which allows foreign DNA to be inserted into a host cell…

1979

#13980

Expression in Escherichia coli of chemically synthesized genes for human insulin (plasmid construction / lac operon / fused proteins / radioimmunoassay / peptide purification).

Working at Genentech, Kleid and Goeddel and colleagues were the first scientists to apply genetic engineering techniques, incorporating chemically synthesized DNA encoding human insulin into E. coli, that expressed, a…

1979

#14345

An annotated bibliography of Canadian medical periodicals, 1826-1975.

In 2002 David Crawford began updating this work online as Bibliography of Canadian health sciences periodicals 1826-1980. This and other related writings by Crawford are available at https://internatlibs.mcgill.ca/.

1980

#8175

Applications of artificial intelligence for organic chemistry: The Dendral project.

1980

#11220

Incunabula Short Title Catalogue (ISTC).

https://data.cerl.org/istc/_search The Incunabula Short Title Catalogue (ISTC) , an electronic bibliographic database maintained by the British Library, seeks to catalogue all known incunabula. The database lists book…

1980

#11488

The seeds of artificial intelligence: SUMEX-AIM.

A semi-popular and extensively illustrated summary of research on artificial intelligence in medicine at Stanford Medical School as directed by Edward A. Feigenbaum, Stanley N. Cohen, Carl Djerassi, and Elliott C. Lev…

1981

#6007.2

Ophthalmologisch-optische Untersuchungsgeräte.

English translation by F.C. Blodi as The history of optical instruments for the examination of the eye, Bonn: J. P. Wayenborgh, 1986.

1981

#9728

The DNA story: A documentary history of gene cloning.

1981

#13285

Establishment in culture of pluripotential cells from mouse embryos.

Evans and Kauffman were the first to identify, isolate and successfully culture embryonic stem cells using mouse blastocysts. This discovery opened the doors to the creation of “murine genetic models” -- mice that hav…

1981

#13961

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells (embryonic stem cells/inner cell masses/differentiation in vitro/embryonal carcinoma cells/growth factors) .

Martin used a different approach that avoided in vivo alteration. She reasoned that an ES cell line might be obtained by culturing cells isolated from blastocysts in a medium that had previously been conditioned by an…

1981

#14183

Computer averaging of electron micrographs of the 405 ribosomal subunit.

Frank and colleagues developed a method that allows sorting of particle images into classes based on their orientation, as well as their structural features. Specifically Frank developed mathematical tools used for im…

1982

#7431

A history of the National Library of Medicine: The nation's treasury of medical knowledge.

Digital facsimile from the National Library of Medicine at this link; from the Internet Archive at this link. Chapter XX is "Evolution of Computerized Bibliographies."

1982

#10046

Splicing life: A report on the social and ethical issues of genetic engineering with human beings.

Digital facsimile from the Internet Archive at this link.

1982

#14018

Agrobacterium rhizogenes inserts T-DNA into the genomes of the host plant root cells.

Chilton was the first (1977) to demonstrate the presence of a fragment of Agrobacterium Ti plasmid DNA in the nuclear DNA of crown gall tissue. Her research on Agrobacterium also showed that the genes responsible for …

1983

#272

History of staining by Harold J. Cohn. 3rd edition by George C. Lusk and Frederick H.Kasten.

1983

#13975

Metallothionein - human GH fusion genes stimulate growth of mice.

Brinster and Palmiter created the first "transgenic" animals, transferring non-native genes into mice through genetic engineering techniques. The cover of the issue of Science magazine in which this paper was publishe…

1983

#13989

Expression of chimaeric genes transferred into plant cells using a Ti-plasmid-derived vector.

Schell and Montagu discovered the gene transfer mechanism between Agrobacterium and plants, which resulted in the development of methods to alter Agrobacterium into an efficient delivery system for gene engineering in…

1984

#11363

Readings in medical artificial intelligence: The first decade. Edited by William Clancey and Edward H. Shortliffe.

1984

#14184

Cryo-electron microscopy of viruses.

Dubochet and colleagues introduced "Dubochet's vitrification method" to vitrify water by cooling it so rapidly that it solidified to form a glass instead of crystals. Using this method, the authors published the first…

1985

#9835

Perseus Digital Library. Gregory R. Crane, Editor-in-Chief.

http://www.perseus.tufts.edu/hopper/ "The Perseus Digital Library Project began at Tufts University, Medford/Somerville, Massachusetts in 1985. Though the project was ostensibly about Greek and Roman literature and cu…