Facets

1529

#1959.1

Caelii Aureliani Siccensis Tardarum passionum libri V. D. Oribasii Sardi Iuliani Caesaris archiatri Euporiston lib: III. Medicinae comperi: lib: 1. Curationum lib: 1. Trochiscoru confect: lib: 1.

From a clinical point of view, the two works of Caelius Aurelianus, which were translated into Latin from Greek originals by Soranus of Ephesus that were later lost, represent the high-point of Graeco-Roman medical ac…

1582

#7327

Aigentlich Beschreibung der Raiss, so er vor diser Zeit gegen Auffgang inn die Morgenländer, fürnemlich Syriam, Iudaeam, Arabiam, Mesopotamiam, Babyloniam, Assyriam, Armeniam etc....

Rauwolf provided the first modern descriptions of the flora of the area east of the Levantine coast. He was also the first to describe the riparian flora of the Euphrates, and the first European to publish an account …

1673

#12972

Nova medicina spirituum: Curiosa scientia & doctrina, unanimiter hucusque neglecta, & à nemine meritò exculta, medicis tamen & physicis utilissima. In quâ Primo Spirituum naturalis constitutio, vita, sanitas temperamenta, ingenia, calidum innatum, phantasiae vires, ideae, astrorum influentiae, μετεμψύχωσις, rerum magnetissimi, sympatiae & antipatiae, qualitates hactenus occultae, aliaq; caeteroquin abstrusa & paradoxa; Dehinc spirituum praeternaturalis seu morbosa Dispositio, causae, curationes per naturam, per diaetam, per arcana majora, palingenesiam, magnetissimum seu sympatheismum, transplantationes, amuleta, ingenuè & dilucidè demonstrantur.

”A very curious work, attributing the causes of many diseases to spirits and basing their cure on this theory. There is a great deal on insanity. The methods of treatment are partly chemical, partly magnetical, even s…

1684

#1311

Dr. Willis's practice of physick.

The only complete edition of Willis's works in English, translated by the poet Samuel Pordage. It contains the translations of all his works except his Affectionum quae dicuntur hystericae (1671). The collection inclu…

1752

#11719

Sendschreiben von den Wirkungen des Kafeetranks.

Discussing the consumption and reception of coffee from Britain to Turkey, Knoll dismissed criticisms of coffee, including that it reduced beauty and virility, or that it was contrary to Islam, instead promoting the m…

1767

#2103

Ricerche fisiche sopra il veleno della vipera.

The starting point of modern investigations of serpent venoms and their antidotes. This work also includes Fontana’s description of the ciliary canal in the eye of an ox. This structure does not appear in the human ey…

1822

#4521

On a peculiar disease resulting from the use of ardent spirits.

Jackson drew attention to alcoholic neuritis – arthrodynia a potu. Jackson was professor at Boston Medical School.

1837

#4524

On the influence of electricity, as a remedy in certain convulsive and spasmodic diseases.

First therapeutic employment of static electricity.

1845

#2077.2

Du hachische et de l’aliénation mentale: Études psychologiques.

Moreau's experments may have been the first medical experiments with a psychotropic agent in the treatment of mental illness. English translation by G. J. Barnett as Hashish and mental illness (New York: Raven Press, …

1866

#13251

On uncontrollable drunkenness considered as a form of mental disorder. With suggestions for its treatment, and the organization of sanitoria for dipsomanics.

Digital facsimile from Google Books at this link.

1867

#3914.1

On researches intended to promote an improved chemical identification of diseases.

Discovery of the first porphyrin, hematoporphyrin (p. 227). Hematoporphyrin has also been used as an antidepressant and antipsychotic since the 1920s,

1868

#4539

Drunkard’s or alcoholic paraplegia.

Classic account of alcoholic paraplegia.

1869

#1869

Das Chloral, ein neues Hypnoticum.

Demonstration of the value of chloral hydrate as a hypnotic. See also his monograph Das Chloralhydrat, Berlin, 1869.

1884

#1880.1

Ueber coca.

Freud described his observations (with himself as subject) on the effects of cocaine, including its abolition of hunger and fatigue, the “exhilaration and lasting euphoria”. He also described its supposed non-addictiv…

1886

#1883.01

Om Periodiske Depressionstilstande og deres Patogenese.

Lange was the first to use a mixture of drugs containing lithium carbonate for the preventive treatment of periodic depression. This work contains the “first unequivocal account of prophylactic drug treatment for an e…

1887

#4945

Disturbance of psychic activity in alcoholic paralysis.

“Korsakoff’s psychosis” or syndrome – alcoholic polyneuritis with loss and falsification of memory. A second paper on the subject in Ezhened. klin. Gaz., 1889, 9, 85, 115, 136, is translated into English in Neurology,…

1887

#7917

Über einige Derivate der Phenylmethacrylsäure und der Phenylisobuttersäure.

Synthesis of phenylisopropylamine, later known as amphetamine. Its stimulant effects were unknown until it was independently resynthesized by Gordon Alles.

1889

#2100

Des polynévrites en général et des paralysies et atrophies saturnines en particulier.

Madame Dejerine-Klumpke, famous neurologist, contributed an important work on lead palsies.

1893

#7019

Kanyaku maou seibun kenkyuu seiseki (zoku).

Nagai synthesized methamphetamine from ephedrine.

1898

#1890.1

Ueber Pellote. Beiträge zur chemischen und pharmakologischen Kenntniss der Cacteen. Zweite Mitteilung.

Isolation of mescaline, the active agent in peyote. One of the first scientific investigations of a psychedelic drug.

1903

#1892

Ueber eine neue Klasse von Schlafmitteln.

Synthesis of barbitone (Barbitol), the first available barbiturate.

1903

#4955

Sopra un’ alterazione del corpo calloso osservata in soggetti alcoolisti.

Marchiafava–Bignami disease – degeneration of the corpus callosum in alcoholism.

1908

#8246

Insanity in India: Its symptoms and diagnosis; with reference to the relation of crime and insanity.

Includes considerable discussion of the psychoactive effects of cannabis. Digital facsimile from the Hathi Trust at this link.

1914

#1341

Acetylcholine, a new active principle of ergot.

Isolation of acetylcholine in ergot.

1918 –1919

#4806

Ueber die Einwirkung der Malaria auf die progressive Paralyse.

In 1917 Wagner von Jauregg returned to the idea of the inoculation of paretics with malaria to induce pyrexia, first proposed by him in 1887 (Ueber die Einwirkung fieberhafter Erkrankungen auf Psychosen, Jb. Psychiat.…

1919

#8795

Über die Anhalonium-Alkaloide I. Anhalin und Mezcalin

Synthesis of mescaline.

1924

#2086

Phantastica.

The classic of psychoactive drug classification. Lewin established the following categories: Euphorics, Phantastics, Inebriants, Hypnotics, and Excitants. English translation, 1931.

1927

#2086.1

Der Meskalinrausch. Seine Geschichte und Erscheinungsweise.

The most comprehensive treatise on peyote and its active agent, mescaline, which was synthesized in 1919.

1928

#8796

Mescal: The "divine" plant and its psychological effects. With an introduction by Macdonald Critchley.

The first study of the psychological effects of mescaline.

1929

#1978

The use of a new apparatus for the prolonged administration of artificial respiration. I. A fatal case of poliomyelitis.

The Drinker respirator (“iron lung”).

1929

#5712

Induction of anesthesia in man by intravenous injection of sodium isoamyl-ethyl barbiturate.

Sodium amytal (Amobarbitol). With J. T. C. McCallum, H. A. Shonle, E. E. Swanson, J. B. Scott, and G. H. A. Clowes.

1930

#4765

A report of progress on the use of ephedrine in a case of myasthenia gravis.

Harriet Edgeworth discovered by accident the beneficial effect of ephedrine in myasthenia gravis. Digital facsimile from jamanetwork.com at this link.

1930

#7918

Clinical observations on phenylethanolamine sulfate.

In 1929 Alles discovered the sympathomimetic properties of beta-phenyl-isopropylamine (amphetamine). With G. Piness and H. Miller.

1931

#4959

Rauwolfia serpentina, a new Indian drug for insanity and high blood pressure.

Introduction of reserpine in the treatment of psychoses.

1933

#1923

The pharmacological action of an alkaloid obtained from Rauwolfia serpentina Benth. A preliminary note.

R. N. Chopra, J. C. Gupta, and B. Mukherjee demonstrated the sedative and hypotensive effect of an alkaloid isolated from Rauwolfia serpentina (reserpine).

1934

#4960

Schizophreniebehandlung mittels Insulin-Hypoglykämie sowie hypoglykämischer Schocks.

Insulin shock therapy of schizophrenia. Sakel wrote several subsequent papers on this subject in the same journal. English version in Amer. J. Psychiat., 1937, 93, 829-41.

1935

#4961

Versuche über die biologische Beeinflussung des Ablaufes der Schizophrenic. 1. Campher-und Cardiazolkrämpfe.

Cardiazol (metrazol) convulsion therapy of schizophrenia was introduced by Meduna in 1934.

1936

#7919

Effect of Benzedrine sulfate on mood and fatigue in normal and neurotic persons.

Myerson, an American neurologist, psychiatrist, clinician, pathologist, and researcher, funded by Benedrine manufacturer Smith, Kline and French, promoted Benzedrine (i.e. amphetamine) as an anti-depressant, leading t…

1936

#9304

The ethnobiology of the Chiricahua and Mescalero Apache: A. the use of plants for food, beverages and narcotics. Ethnobiological studies in the American Southwest, Vol. 3. Biological series (Vol. 4, No. 5); Bulletin, University of New Mexico, whole, (No. 297).

1937

#7980

Behavior of children receiving benzedrine.

Bradley showed that racemic amphetamine, that is, the 50:50 mixture of d- and l-amphetamine isomers (Benzedrine®), was shown to reduce the impulsivity, distractibility, and inattention characteristic of Attention Defi…

1938

#4962

Un nuovo metodo di shockterapia: “L’elettroshock”. (Riassunto.)

Introduction of electric convulsion therapy.

1943

#1928.1

Partialsynthese von Alkaloiden vom Typus des Ergobasins.

Synthesis of lysergic acid diethylamide (LSD).

1944

#4689.1

Penicillin in the treatment of meningitis.

1949

#1930.1

Lithium salts in the treatment of psychotic excitement.

The first clinical trial of lithium.

1952

#1931

Reserpin, der sedative Wirkstoff aus Rauwolfia serpentina Benth.

Isolation of reserpine. With E. Schlittler and H. J. Bein.

1952

#4962.3

Trente-huit cas de psychoses traitées par la cure prolongée et continue de 4560 R. P. C. R. Congr. Alien, et Neurol, de Langue Franç.

Introduction of chlorpromazine in the treatment of psychosis. Chlorpromazine was later marketed in the United States as Thorazine.

1953

#1931.1

Propriétés pharmacodynamiques du chlorhydrate de chloro-3 (diméthylamino-3’propyl) -10 phénothiazine (4.560 R.P.).

Chlorpromazine. With J. Foumel, R. Ducrot, M. Kolsky, and P. Koetschet. Chloropromazine was later marketed in the United States as Thorazine.

1954

#4962.4

The pharmacological properties of 2-methyl-2-m-propyl-1, 3-propanediol dicarbamate (Miltown), a new interneuronal blocking agent.

Introduction of meprobamate, later used for the treatment of anxiety. Miltown was the first widely prescribed psychotropic drug.

1954

#7981

Ritalin, a new synthetic compound with specific analeptic components.

The authors identified Methylphenidate as a stimulant. It is sold under the trade name Ritalin, and other names.

1960

#1931.3

The psychosedative properties of methaminodiazepoxide.

Librium. With four co-authors.