Facets

1984

#14263

Molecular analysis of the period locus in Drosophila malanogaster and identification of a transcript involved in biological rhythms.

Rosbach and colleagues, including Jeffrey C. Hall, sequenced the Drosophila period gene in 1984. Full text available from cell.com at this link. Order of authorship in the original publication: Reddy, Zehring, Wheeler…

1984

#14265

Restoration of circadian behavioral rhythms by gene transfer in Drosophila.

"At The Rockefeller University in the early 1980s, Young and his two lab members, Ted Bargiello and Rob Jackson, further investigated the circadian period gene in Drosophila. They constructed segments of recombinant D…

1985

#8388

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.

Blackburn and Grieder discovered telomerase in the ciliate Tetrahymena. In 2009 Blackburn and Grieder shared the Nobel Prize in Physiology or Medicine with Jack W. Szostak "for the discovery of how chromosomes are pro…

1985

#8883

The collected essays of Sir William Osler. 3 vols. Edited by John P. McGovern and Charles G. Roland.

Vol. 1: The philosophical essays. Vol. 2: The educational essays. Vol. 3: The historical and biographical essays.

1985

#10785

Enzymatic amplication of B-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.

Polymerase chain reaction first published. With Randall K. Saiki, Stephen Scharf, Fred Faloona et al. Order of authorship in the original paper was Saiki, Scharf, Faloona, Mullis.... In 1993 the Nobel Prize in Chemist…

1985

#11060

Structure of the protein subunit in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3 Å resolution.

Discovery of the three-dimensional structure of a protein complex found in certain photosynthetic bacteria, called the photosynthetic reaction center. This was the first elucidation of the 3D crystal structure of any …

1985

#14339

Filamentous fusion phage: Novel expression vectors that display cloned antigens on the virion surface.

In this paper Smith invented "phage display technology," a technique where a specific protein sequence is artifically inserted into the coat protein gene of a bacteriophage, causing the protein to be expressed on the …

1986

#8088

The path we tread: Blacks in nursing, 1854-1984.

1986

#10009

L'Art dentaire à travers la peinture.

1988

#8791

Passage of darkness: The Ethnobiology of the Haitian zombie.

1989

#8087

Black women in white: Racial conflict and cooperation in the nursing profession, 1890-1950.

1993

#14010

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.

Ambros and colleagues discovered the first known microRNA (miRNA), a small single-stranded non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA sil…

1993

#14301

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans.

The authors cloned and generated the sequence of the lin-14 gene. They discovered that a segment in lin-14 mRNA (messenger RNA), was necessary for its inhibition by lin-4. Ruvkun and Ambros (No. 14010) then compared r…

1994

#10090

Secret doctors: Ethnomedicine of African Americans.

"Based on an ethnographic study of the traditional medicine of African Americans in the rural southern United States, this work concentrates on the original Louisiana Territory, with its Native and African American in…

1994

#13564

Green fluorescent protein as a marker for gene expression.

Chalfie and colleagues showed that the green fluorescent protein (GFP) from the jellyfish Aequorea victoria, could be used as a visible marker for protein localization and expression in vivo, in bacteria and worm cell…

1994

#14261

Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization.

Order of authorship in the original publication: Baba, M., Takeshige, Baba, N., Ohsumi. In 2016 Oshuni received the Nobel Prize in Physiology or Medicine "for his discoveries of mechanisms for autophagy."

1994

#14314

Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria.

Walker used X-ray crystallography to determine the structure of ATP synthase (ATPase or adenosine triphosphatase). In 1997 Walker shared the Nobel Prize in Chemistry with Paul Boyer and Jens C. Skou “for their elucida…

1996

#13565

Crystal structure of Aequorea victoria green fluorescent protein.

Tsien and colleagues published the crystal structure of the 238 A.A. long green fluorescent protein (GFP). With this data, the authors could determine what had to be modified within the protein in such a way that the …

1998

#12553

African American midwifery in the South: Dialogues of birth, race, and memory.

1998

#13957

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.

The authors reported that tiny snippets of double-stranded RNA (dsRNA) effectively shut down specific genes, driving the destruction of messenger RNA (mRNA) with sequences matching the dsRNA. As a result, the mRNA can…

1999

#9224

African-American dental surgeons and the U.S. Army Dental Corps: A struggle for acceptance, 1901-1919.

Digital text from the U.S. Army Medical Department Office of Medical History at this link. (This study does not seem to have been formally published; WorldCat is uncertain of its publication date.)

1999

#10315

Against the odds: Blacks in the profession of medicine in the United States.

1999

#13080

Early black American leaders in nursing: Architects for integration and quality. (National League for Nursing Series).

1999

#14262

A pdf Neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila.

In 2017 Hall shared the Nobel Prize in Physiology or Medicine with Michael Rosbash and Michael W. Young “for their discoveries of molecular mechanisms controlling the circadian rhythm.” Order of authorship in the orig…

2000 –2002

#8081

An American health dilemma: A medical history of African Americans and the problem of race. Vol. 1: Beginnings to 1900. Vol. 2: Race, medicine and health care in the United States 1900-2000.

2000

#13883

NDA II. The story of America's second National Dental Association.

2000

#13952

Structure of the 30S ribosomal subunit.

Ramakrishnan and colleagues determined the complete molecular structure of the 30S subunit of the ribosome and its complexes with several antibiotics. " The Abstract: "Genetic information encoded in messenger RNA is t…

2000

#13953

The structural basis of ribosome activity in peptide bond synthesis.

With Poul Nissen, Jeffrey Hansen, Nenad Ban, Peter B. Moore. Steitz shared the 2009 Nobel Prize in Chemistry with Venkatraman Ramakrishnan and Ada Yonath "for studies of the structure and function of the ribosome."

2000

#13982

Architecture of RNA polymerase II and implications for the transcription mechanism.

Kornberg devoted two decades to the development of methods to visualize the atomic structure of RNA polymerase and its associated protein components. Initially, Kornberg took advantage of expertise with lipid membrane…

2001

#12145

Aristotle on life and death

2002

#8011

African American alternative medicine: Using alternative medicine to prevent and control chronic diseases.

2002

#8706

Darwin Online. The complete works of Charles Darwin, edited by John van Wyhe.

http://darwin-online.org.uk/AboutUs.html Darwin's Complete Publications Books Origin of Species, Voyage of the Beagle, Descent of Man... Articles Volcanic, Darwin-Wallace paper... Published Letters Life and letters, D…

2003

#14300

Design of a novel globular protein fold with atomic-level accuracy.

Called, "the breakthrough in computational de novo protein design." This was the proof of concept paper that computers and AI could be used to predict protein structures accurately and much faster than with convention…

2005

#13622

Suppression of RNA recognition by toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA.

Karikó and Weissman discovered the nucleoside modifications that suppress the immungenicity of RNA, leading to their patents for the application of non-immunogenic, nucleoside-modified RNA (modRNA). This technology wa…

2005

#14257

Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release.

Südhof is credited with discovering much of the machinery mediating neurotransmitter release and presynaptic plasticity, beginning with the discovery of symaptotagmins and their role in neurostrasmitter release from t…

2006

#13094

The Pauling catalogue. Ava Helen and Linus Pauling papers at Oregon State University. Edited by Christoffer Petersen and Cliff Mead. 6 vols.

Vol. 1. Timeline, correspondence, publications, manuscripts & typescripts of articles, speechs, and books. Vol. 2. Science, Research Notebooks. 1917 Linus Pauling Diary. Vol. 3. Peace, Ava Helen Pauling, travel, honor…

2006

#13287

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Takahashi and Yamanaka reprogrammed mice fibroblast cells, which can produce only other fibroblast cells, to become pluripotent stem cells, which have the capacity to produce many different types of cells. This they a…

2006

#14048

An inconvenient truth. The planetary emergency of global warming and what we can do about it.

A politician, Gore was one of the first to draw popular attention to climate change. He supplemented the best-selling book with a film and DVD with the same title. Ten years later, recognizing that in spite of its wid…

2007

#9976

African American folk healing.

2007

#10371

Race & medicine in nineteenth and early twentieth-century America.

2009

#14357

Milton and maternal mortality.

"All too often, childbirth in early modern England was associated with fear, suffering and death, and this melancholy preoccupation weighed heavily on the seventeenth-century mind. This landmark study examines John Mi…

2011

#14134

Crystal structure of the β2 adrenergic receptor–Gs protein complex.

Kobilka and colleagues published the crystal structure of a beta-2 receptor forming a complex with the G protein coupled receptor. This was the first time that a complete complex of an active receptor and it's Gs prot…

2012

#11844

A programmable dual RNA-guided DNA endonuclease in adaptive bacterial immunity.

Order of authorship in the original publication: Jinek, Chylinski, Fonfar, Hauer, Doudna, Charpentier. Doudna, Charpentier and colleagues showed for the first time that the CRISPR evolutionary immune tool of bacteria …

2014

#7289

The complete genome sequence of a Neanderthal from the Altai Mountains.

First complete sequence of a Neanderthal genome. With more than 20 co-authors. In 2022 Pääbo was awarded the Nobel Prize in Physiology or Medicine "for his discoveries concerning the genomes of extinct hominins and hu…

2016

#10421

Vanishing America: Species extinction racial peril, and the origins of conservation.

"Nineteenth-century citizens of European descent widely believed that Native Americans would eventually vanish from the continent. Indian society was thought to be tied to the wilderness, and the manifest destiny of U…

2017

#9907

Medicalizing blackness: Making racial difference in the Atlantic world, 1780-1840.

2017

#12851

The smile revolution in eighteenth century Paris.

2018

#11382

Rhetoric, medicine, and the woman writer, 1600–1700.

"How did physicians come to dominate the medical profession? Lyn Bennett challenges the seemingly self-evident belief that scientific competence accounts for physicians' dominance. Instead, she argues that the whole e…

2021

#14026

Highly accurate protein structure prediction with AlphaFold.

Abstract: "Proteins are essential to life, and understanding their structure can facilitate a mechanistic understanding of their function. Through an enormous experimental effort1,2,3,4, the structures of around 100,0…

2022

#14059

Masters of health: Racial science and slavery in U.S. medical schools.