Facets

1833

#6028

Traité pratique des maladies de l’utérus et de ses annexes. 2 vols. and atlas.

Boivin and Dugès practiced amputation of the cervix for chronic ulceration. On page 648 of vol. 2 is the first recorded case of cancer of the female urethra. English translation, 1834.

1898

#2003

Sur une substance nouvelle radio-active, contenue dans la pechblende.

The Curies, studying the radioactivity of minerals containing uranium and thorium, isolated from pitchblend a substance which they called radium and which they showed to possess an astonishing degree of radioactivity.…

1902

#3780

On the pathological changes in Hodgkin’s disease, with especial reference to its relation to tuberculosis.

Dorothy Reed’s classic work on Hodgkin’s disease included a study of the histological picture. She described the proliferation of the endothelial and reticular cells, and the formation of lymphadenoma cells – “Dorothy…

1905 –1906

#1180

An experimental enquiry into the factors which determine the growth and activity of the mammary glands.

In their classic paper on the mammary gland, these workers attributed its changes during pregnancy to the fetus.

1906

#3959

Morphology and physiology of areas of Langerhans in some vertebrates

Lydia De Witt ligated the pancreatic ducts and obtained extracts from the islets of Langerhans in cats, noting their glycolytic qualities.

1907

#2596

De l’anaphylaxie et de l’anti-anaphylaxie vis-à-vis du sérum de cheval.

“Anti-anaphylaxis” was the term given by Besredka and Steinhardt to the specific desensitization of sensitized animals.

1911

#2638

Zur Diagnose des Karzinoms.

A serum reaction, employed by Freund and Kaminer in 1910 for the diagnosis of cancer.

1916

#2642

Further investigations on the origin of tumours in mice. III. On the part played by internal secretion in the spontaneous development of tumours.

Demonstration of the influence of an internal secretion on the development of spontaneous cancer. Castration of female mice of a strain in which mammary cancer was frequent reduced its incidence and delayed its growth.

1924

#5083

A scarlet fever antitoxin.

Following their successful attempts to establish individual susceptibility to scarlet fever, these workers prepared an antitoxin for immunization.

1924

#5084

The significance of Streptococcus hemolyticus in scarlet fever and the preparation of a specific anti-scarlatinal serum by immunization of the horse to Streptococcus hemolyticus-scarlatinae.

Dochez and Sherman immunized a horse by repeated injections of scarlet fever toxin. A serum obtained from the horse blanched a scarlet fever rash and, when injected subcutaneously, caused marked amelioration of the ea…

1926

#5782.1

A further report on cancer of the breast, with special reference to its associated antecedent conditions.

First modern case-control study.

1928

#2652

Cancer and heredity.

By selective breeding over a period of 15 years, Slye produced generations of mice absolutely resistant to, or particularly susceptible to, cancer. She demonstrated that resistance is a Mendelian dominant and suscepti…

1931

#4670.5

Immunological differences between strains of poliomyelitis virus.

1932

#3923.1

A new error of tyrosine metabolism: tyrosinosis, intermediary metabolism of tyrosine and phenylalanine.

1934

#5045

A new antigen of B. typhosus. Its relation to virulence and to active and passive immunisation.

Vi antigens first described.

1935

#2576.3

A protective action of neurotropic against viscerotropic yellow fever virus in Macacus rhesus.

One of the first examples of an animal virus interference phenomenon was demonstrated by Hoskins.

1936

#5484.2

Propagation of rabies virus in tissue culture and the successful use of culture virus as antirabic vaccine.

Webster and Clow succeeded in growing rabies virus in tissue culture.

1937

#1925

Action protectrice des éthers phénoliques au cours de l’intoxication histaminique.

First description of structure and action of an antihistamine. In 1957 Bovet was awarded the Nobel Prize in Physiology or Medicine “for his discoveries relating to synthetic compounds that inhibit the action of certai…

1937

#2659

The carcinogenic action of oestrone: induction of mammary carcinoma in female mice of a strain refractory to the spontaneous development of mammary tumours.

With L. H. Stickland and K. I. Connal.

1938

#2576.7

Recherches sur le phénomène de Twort-d’Hérelle (bactériophage ou autolyse hérédo-contagieuse).

The Wollmans made important contributions to the knowledge on bacteriophage and lysogeny.

1939

#5087.2

A study in active immunization against pertussis.

Pertussis vaccine.

1939

#6231

Prediction and prevention of late pregnancy accidents in diabetes.

First report of hormone treatment. Written with R.S. Titus, E.P. Joslin, and H. Hunt.

1940

#1173.1

Interstitial cell stimulating hormone. II. Method of preparation and some physico-chemical studies.

Choh Hao Li and colleagues isolated of the interstitial cell stimulating (luteinizing) hormone.

1941

#2578

The absorption of influenza virus by red cells and a new in vitro method of measuring antibodies for influenza virus.

Independently of Hirst, McClelland and Hare discovered virus hemagglutination.

1942

#2578.1

Sensitization to horse serum by means of adjuvants.

Freund’s adjuvant. Freund’s procedure allowed adjuvants to be used for any antigen.

1942

#2578.2

Pneumococcus polysaccharide as a paralyzing agent on the mechanism of immunity in white mice.

1942

#2700.01

Metabolic studies on neoplasm of bone with the aid of radioactive strontium.

Radioisotopic bone scanning. With B. Low-Beer, H. Friedell, and J. Lawrence.

1943

#1174

Adrenocorticotropic hormone.

Choh Hao Li and colleagues Isolated pure adrenocorticotropic hormone (ACTH) from sheep pituitary glands.

1944

#2659.2

“Folic acid” a tumor growth inhibitor.

Inhibition of tumor growth by a folic acid concentrate. With R. Lewisohn, D. Laszlo. These workers later (Proc. Soc. exp. Biol. N. Y., 1944, 56, 144-45) obtained similar results with xanthopterin.

1945

#1175.1

Isolation and properties of the anterior hypophyseal growth hormone.

Choh Hao Li and colleagues isolated the anterior pituitary growth hormone.

1945

#3869

A tentative test for pheochromocytoma.

The Roth–Kvale histamine test for the diagnosis of pheochromocytoma.

1946

#3106

Leukaemia treated with urethane compared with deep x-ray therapy.

Urethane in treatment of leukemia. With A. Haddow, I. Ap Thomas, and J. M. Watkinson.

1948

#4154.1

Melanomas of childhood.

Spitz first defined the histologic criteria for the diagnosis of juvenile melanoma.

1949

#1175.2

Isolation of pituitary follicle-stimulating hormone (FSH).

By Choh Hao Li and colleagues.

1953

#1138.1

3:5:3'-Triiodothyronine. I. Isolation from thyroid gland and synthesis.

Discovery of the second thyroid hormone, triiodothyronine. Digital facsimile from PubMedCentral at this link.

1956

#2353.1

Freeze-dried B.C.G. vaccination of newborn infants with a British vaccine.

Freeze-dried B.C.G. vaccine.

1956

#7782

Preliminary communication: Malignant disease in childhood and diagnostic irradiation in-utero.

Stewart was one of the earliest to study the effect of prenatal X-rays, later replaced by ultrasound. She found that the children of mothers who received these X-rays were almost twice as likely to develop leukemia or…

1957

#2660.10

The induction of neoplasms with a substance released from mouse tumors by tissue culture.

Isolation of polymavirus (papovavirus). With B. E. Eddy, A. M. Gochenour, N. G. Borgese, and G E. Grubbs.

1957

#2578.23

Leukocyte agglutinins in human sera. Correlations between blood transfusions and their development.

Leucocyte typing.

1960

#2660.13

Virus-cell interaction with a tumour-producing virus.

Polyomavirus (papovavirus) shown to be capable of transforming cells in culture. Full text from PubMedCentral at this link.

1960

#2578.28

Immunosassay of endogenous plasma insulin in man.

First radioimmunoassay of a hormone, a test capable of estimating nonogram or even picogram quantities. In 1977 Yalow received half of the Nobel Prize in Physiology or Medicine "for the development of radioimmunoassay…

1963

#3924.4

A simple phenylalanine method for detecting phenylketonuria in large populations of newborn infants.

Bacterial inhibition test for phenylketonuria.

1964

#2660.17

Cultivation in vitro of human lymphoblasts from Burkitt’s malignant lymphoma.

Order of authorship in the original publication: Epstein, Barr. Discovery of the Epstein-Barr virus, a human herpes virus causing infectious mononucleosis, and implicated in Burkitt’s lymphoma and other forms of cance…

1964

#2660.18

Virus particles in cultured lymphoblasts from Burkitt’s lymphoma.

Order of authorship in the original publication: Epstein, Achong, Barr. Presence of herpes-like virus particles in Burkitt’s tumor cells reported. The Epstein-Barr virus was the first human cancer-causing virus to be …

1968

#3108.9

Arabinosyl cytosine: A useful agent in the treatment of acute leukemia in adults.

Cytosine arabinoside. With J. P. Holland, M. Weil, et al.

1988

#10452

A history of the Imperial Cancer Research Fund 1902-1986.

"The author takes a broad perspective and provides a comparative framework by discussing the changing relationship between the ICRF and the medical profession, government, and other charities, notably the Cancer Resea…

1994

#7066

Positional cloning of the mouse obese gene and its human homologue.

Discovery of the hormone leptin and its role in regulating body weight. Friedman and associates subsequently found that injections of the encoded protein, leptin, decrease body weight of mice by reducing food intake a…

1995

#10914

Kaposi's Sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas.

Chang, Moore and colleagues showed that the virus causing Kaposi's Sarcoma also causes body cavity lymphomas and lymphomatous effusions in humans. (Thanks to Juan Weiss for this reference and its interpretation.)

2003

#10709

Conjoined twins: An historical, biological and ethical issues encyclopedia.

2005

#13622

Suppression of RNA recognition by toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA.

Karikó and Weissman discovered the nucleoside modifications that suppress the immungenicity of RNA, leading to their patents for the application of non-immunogenic, nucleoside-modified RNA (modRNA). This technology wa…