Facets

1929

#1933

On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae.

Discovery of the growth-inhibiting action of Penicillium on certain bacteria. In 1945 Fleming shared the Nobel Prize in Physiology or Medicine with Ernst Boris Chain and Sir Howard Walter Florey "for the discovery of …

1932

#10784

On the specific antibacterial properties of penicillin and potassium tellurite. Incorporating a method of demonstrating some bacterial antagonisms.

In this paper Fleming first described the use of penicillin as an antibacterial agent in man, and reported on experiments using it as a wound dressing for septic wounds. He also corrected the species name from Penicil…

1945

#2350

Streptomycin in treatment of clinical tuberculosis: a preliminary report.

1946

#5261.1

Chloroquine for treatment of acute attacks of vivax malaria.

Harry Most led the development of chloroquine for use in treating American troops suffering from malaria. At the beginning of the American involvement in the war there were more American casualties from malaria than f…

1947

#1937

“Aerosporin”, an antibiotic produced by Bacillus aerosporus Greer.

Discovery of aerosporin (polymyxin). With A. M. Brown and G. Brownlee.

1947

#5351.3

Experimental chemotherapy of filariasis. III. Effect of 1-diethylcarbamyl-4-methyl-piperazine hydrochloride against naturally acquired filarial infections in cotton rats and dogs.

Proof of antifilarial action of diethylcarbarmazine citrate (hetrazan). With S. Kushner, H. W. Stewart, E. White, W. S. Wallace, and Y. Subbarow.

1947

#5351.4

Sur la chimiothérapie de l’onchocercose. (Note préliminaire).

First effective chemotherapy (suramin) for onchocerciasis. With C. Heurard, E. Peel, and M. Wanson.

1948

#5261.2

Pentaquine (Sn-13,276), a therapeutic agent effective in reducing the relapse rate in vivax malaria.

Clinical trials of pentaquine. With B. Craige, R. Jones, C. M. Whorton, T. N. Pullman, and L. Eichelberger.

1949

#11102

Mushrooms in their natural habitats.

A distinctively published work illustrated stereoscopically with color View-Master slides, and incorporating the View-Master "reels" and a View-Master viewer in a box along with the conventional bound text.

1952

#9719

Replica plating and indirect selection of bacterial mutants.

Demonstration of the mutational basis of antibiotic resistance. Digital facsimile from PubMedCentral at this link.

1955

#2527

Reconstitution of active tobacco mosaic virus from its inactive protein and nucleic acid components.

First reconstitution of a virus.

1956 –1960

#86.4

Collected papers of Paul Ehrlich. Compiled and edited by F. Himmelweit. 3 vols.

Vol. I: Histology, biochemistry, and pathology, Vol. 2: Immunology and cancer research; Vol. 3: Chemotherapy. Most texts are in German. English translations are also published when available. The set includes new Engl…

1958

#4011.1

Experimental ringworm in guinea pigs: oral treatment with griseofulvin.

Use of griseofulvin in the treatment of ringworm.

1958

#12215

Les champignons hallucinogenes du Mexique. Études ethnologiques, taxinomiques, biologiques, physiologiques et chimiques.

1964

#5351.6

Chemotherapy of experimental Schistosoma mansoni infections with a nitro-thiazole derivative, CIBA 32, 644-Ba.

Introduction of niridazole (Ambilhar).

1966

#11105

Antibiotic susceptibility testing by a standardized single disk method.

The disk diffusion test, or agar diffusion test, or Kirby–Bauer test (disc-diffusion antibiotic susceptibility test, disc-diffusion antibiotic sensitivity test, KB test), for the antibiotic sensitivity of bacteria. (T…

1968

#9848

Soma: Divine mushroom of immortality.

Ethnomycologist and banker Wasson provided evidence for the important role that hallucinogenic mushrooms - in particular the ubiquitous mushroom Amanita muscaria (fly agaric) - play in various ancient and modern cultu…

1969

#5351.7

A new series of 2-aminomethyltetrahydroquinoline derivatives displaying schistosomicidal activity in rodents and primates.

Oxamniquinine.

1978

#10168

The road to Eleusis: Unveiling the secret of the mysteries.

Argues that the psycho-active ingredient in the secret kykeion potion used in the Eleusinian mysteries was most likely the ergotism causing fungus Claviceps purpurea. Furthermore the book introduced the term "entheoge…

1985

#11377

The association between idiopathic hemolytic uremic syndrome and infection by Verotoxin-producing Escherichia coli.

Order of authorship in the original publication: Karmali, Petric, Lim. The authors discovered that a hemolytic uremic syndrome, associated with E. coli 0157-H7 (first described in No. 11376), and which could not be cu…

1986

#11106

Administration of 3'-Azido-3'-Deoxythmymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex.

Order of authorship in the original publication: Yarchoan, Weinhold, Lyerly. The first antiviral AIDS drug, later named "Retrovir"/ Zidovudine/AZT. (Thanks to Juan Weiss for this reference and its interpretation.)

1999

#11071

Tobacco mosaic virus: Pioneering research for a century. A theme issue edited by B. D. Harrison and T. M. A. Wilson.

2005

#11193

Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: A double blind randomized placebo-controlled trial.

Order of authorship in the original paper: Taylor, Makunde, McGarry.... The authors treated infection by the parasitic worm Wuchereria bancrofti, cause of elephantiasis (lymphatic filariasis), by killing the Wolbachia…

2005

#11481

Glycan foraging in vivo by an intestine adapted bacterial symbiont.

Order of authorship in the original publication: Sonnenberg, Xu, Leip....The authors showed that complex plant carbohydrates (glycans), which the human body cannot digest, provide food for benign bacteria in the micro…

2006

#11772

MykoLibri. Die Biliothek der Pilzbücher.

2007

#11478

Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118.

Order of authorship in the original publication: Corr, Li, Reidel...Hill. The authors discovered that Lactobacilli produce a bacteriocin, a peptidic toxin that inhibits the growth of similar or closely related bacteri…

2008

#9683

Antimicrobial drugs: Chronicle of a twentieth century medical triumph.

Concerns the history of all anti-infectives, including antibacterial, antiviral, antifungal, antiprotozoal and anthelminthic agents.

2013

#8683

Leech.

Published in the "Animal" series. Seemingly a definitive work on the natural history and medical application of leeches.

2016

#11375

Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody.

The cited paper was immediately followed in the same issue of Science by: John Misasi, Morgan A. Gilman, Masaru Kanekiyo et al, "Structural and molecular basis for Ebola virus neutralization by protective human antibo…

2018

#11480

Pathogen elimination by probiotic Bacillus via signaling interference.

Order of authorship in the original publication: Piewngam, Zheng, Nguygen....The authors discovered a mechanism by which probiotics help maintain a healthy microbiome. They showed that Bacillus subtilis can produce a …

2019

#11374

A randomized, controlled trial of Ebola virus disease therapeutics.

Order of authorship in the original publication: Mulangu, Dodd, Davey.... One synthetic drug (Remdesivir, an antiviral) and 3 biologicals were used in this trial. The 3 biologicals were: REGN-EB3, a triple monoclonal …

2019

#11482

Mapping human microbiome drug metabolism by gut bacteria and their genes.

Order of authorship in the original publication: Zimmermann, Simmerman-Kogadeeva, Wegmann....The authors looked at 271 drugs and 68 different species from the main taxonomic microbiome groups. Of the 271 drugs, 176 un…