Facets

1778 –1793

#8222

Geographische Geschichte des Menschen und der allgemein verbreiteten vierfüßigen Thiere: nebst einer hieher gehörigen Zoologischen Weltcharte. 3 vols.

Digital facsimile from the Bayerische StaatsBibliothek at this link.

1843

#7696

Six ethnographic maps illustrative of "The natural history of man".

An atlas of six large hand-colored folding maps originally issued to accompany Prichard's popular work, The natural history of man, first issued in 1843. The maps were revised and re-issued in 1851 and 1861.

1886

#1416

Sulla fina anatomia degli organi centrali del sistema nervoso.

Golgi’s histological studies made a clear conception of the nervous system possible for the first time. He demonstrated the existence of multipolar nerve-cells (Golgi cells) by means of his silver nitrate stain, and d…

1895

#2683

Ueber eine neue Art von Strahlen. (Vorläufige Mittheilung.); Eine neue Art von Strahlen. II. Mittheilung.

The discovery of x rays, which Kölliker later renamed “Roentgen rays”; the foundation stone of the science of roentgenology. English translation in Nature, (February,) 1896, 53, 274 and 377. See also Röntgen’s third p…

1896

#2001

Sur les radiations émises par phosphorescence.

The discovery of radioactivity – research stimulated by Roentgen’s discovery of x rays. In 1903 Becquerel received half of the Nobel Prize in Physics 1903 "in recognition of the extraordinary services he has rendered …

1896

#2684.3

The x-ray and its application to dentistry.

First dental radiography in America.

1896

#3688

The “x” rays in the practice of dental surgery.

Harrison was the first to describe a method of making dental radiographs.

1898

#2003

Sur une substance nouvelle radio-active, contenue dans la pechblende.

The Curies, studying the radioactivity of minerals containing uranium and thorium, isolated from pitchblend a substance which they called radium and which they showed to possess an astonishing degree of radioactivity.…

1912

#6917

Interferenz-Erscheinungen bei Röntgenstrahlen. . . . Eine quantitative Prüfung der Theorie für die Interferenz-Erscheinungen bei Röntgenstrahlen

Discovery of the diffraction of X-rays in crystals. Laue’s discovery was of dual importance: it allowed the subsequent investigation of X-radiation by means of wavelength determination, and it provided the means for t…

1913

#6920

The reflection of x-rays by crystals.

Discovery of X-ray crystallography. The father and son team of physicists, William Henry Bragg and William Lawrence Bragg, constructed the first X-ray spectrometer using crystals as gratings, using a known wavelength …

1917

#3690

Oral roentgenology.

1919

#12507

The microscopic anatomy of the teeth.

Digital facsimile of the 1919 edition from Biodiversity Heritage Library at this link. Mummery substantially expanded and retitled the second edition of this work as The microscopic & general anatomy of the teeth huma…

1923

#9333

The absorption and translocation of lead by plants: A contribution to the application of the method of radioactive indicators in the investigation of the change of substance in plants.

The first application of radioactive tracers in biological studies. Digital facsimile from PubMedCentral at this link. Hevesy received the 1943 Nobel Prize in Chemistry "for his work on the use of isotopes as tracers …

1925

#3692

A new kind of x-ray examination for preventive dentistry.

Original description of technique of making “bite-wing” radiographs.

1926

#14025

The isolation and crystallization of the enzyme urease.

Sumner first isolated and crystallized an enzyme (urease) and proved that enzymes are proteins. One month after publication of the above paper Sumner reinforced his discovery by recrystalizing urease, publishing a fol…

1930

#12830

The moving boundary method of studying the electrophoresis of proteins. (Nova Acta Reg. Soc. Scient. Upsaliensis, IV, 7, No. 4.)

Tilesius's doctoral dissertation introduced the laboratory technique of moving-boundary electrophoresis, a technique for separation of chemical compounds by electrophoresis in free solution. For this work, and the wor…

1931

#12985

Das Problem der dentalen Fokalinfektion und ihre Bekämpfung durch die konservierende Zahnheilkunde.

With physicist Fritz Giesel, Walkhoff on December 28, 1895 Walkhoff did the first dental radiograph on his own teeth. Later, Walkhoff was "responsible for the shift to an everyday use of camphorated chlorophenol to st…

1934

#9340

I. Un nouveau type de radioactivité. II. Séparation chimique des nouveaux radioéléments émetteur d’électrons positifs.

Discovery of artificially produced radionuclides or radioisotopes. In February 1934, the Joliot-Curies reported the first artificial production of radioactive material after discovering radioactivity in aluminum foil …

1935

#2524.5

Isolation of a crystalline protein possessing the properties of tobacco-mosaic virus.

Stanley first crystallized a virus— tobacco mosaic virus. The following year Bawden, Pirie, Bernal and Fankuchen (No. 12005) showed that tobacco mosaic virus molecules are asnisometric and consist of ribonucleoprotein…

1935

#269.5

Das Phasenkontrastverfahren b.d. mikroskopischen Beobachtung.

Zernicke invented phase contrast microscopy. In 1953 Zernike was awarded the Nobel Prize in Physics "for his demonstration of the phase contrast method, especially for his invention of the phase contrast microscope."

1938

#14335

A new method of measuring nuclear magnetic moment.

Order of authorship in the original publication: Rabi, Zacharais,...Kusch. Followed by: (2) The magnetic moments of 3Li6, 3Li7, and 9F19. Physical Review 53, 1938. (3) The molecular beam resonance method for measuring…

1946

#2659.5

The design of a proton linear accelerator.

Linear ion accelerator. In 1968 Alvarez received the Nobel Prize in Physics "for his decisive contributions to elementary particle physics, in particular the discovery of a large number of resonance states, made possi…

1953

#256.4

Helical structure of crystalline deoxypentose nucleic acid.

In 1962 Wilkins shared the Nobel Prize in Physiology or Medicine with Crick and Watson "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living…

1955

#6928

The crystal structure of the hexacarboxylic acid derived from B12 and the molecular structure of the vitamin.

The final structure of vitamin B12. With J. Pickworth, J.H. Robertson, K.N. Trueblood, R.J. Prosen, J. G. White. In 1964 Hodgkin was awarded the Nobel Prize in Chemistry "for her determinations by X-ray techniques of …

1963

#8149

Representation of a Function by its Line Integrals, with Some Radiological Applications.

Cormack showed that changes in tissue density could be computed from x-ray data. Because of limitations in computing power no machine was constructed during the 1960s. Cormack's papers generated little interest until …

1966

#14064

"Fertile" intestine nuclei.

Gurdon and Uehlinger replaced the cell nucleus of frog ova with frog intestinal nuclei to generate tadpoles, some of which became fertile adult male and female frogs. In 2012 the Nobel Prize in Physiology or Medicine …

1968

#13935

Reconstruction of three-dimensional structures from electron micrographs.

Klug and deRosier invented methods for two-dimensional and three-dimensional digital image processing of electron microscope images. The latter method provided the theory behind the development of computed tomography …

1973

#2700.4

Computerized transverse axial scanning (tomography).

Hounsfield invented computer-assisted tomography (CAT), or computed tomography (CT). In 1979 Hounsfield shared the Nobel Prize in Physiology or Medicine with Allen M. Cormack "for the development of computer assisted …

1973

#2700.5

Image formation by induced local interactions: Examples employing nuclear magnetic resonance.

Lauterbur proposed a workable method for using nuclear magnetic resonance to produce images of tissues. In 2003 Lauterbur shared the Nobel Prize in Physiology or Medicine with Sir Peter Mansfield “for their discoverie…

1975

#14182

Three-dimensional model of purple membrane obtained by electron microscopy.

The invention of Cryogenic electron microscopy (cryo-EM). The novel technique was achieved by "by applying the method to tilted specimens, and using the principles put forward by De Rosier and Klug (GM - 13935), for t…

1977

#8150

Medical imaging by NMR.

Mansfield developed a mathematical technique that would allow NMR scans to take seconds rather than hours and produce clearer images than the technique Paul Lauterbur developed in 1973. Mansfield showed how gradients …

1981

#13285

Establishment in culture of pluripotential cells from mouse embryos.

Evans and Kauffman were the first to identify, isolate and successfully culture embryonic stem cells using mouse blastocysts. This discovery opened the doors to the creation of “murine genetic models” -- mice that hav…

1981

#14183

Computer averaging of electron micrographs of the 405 ribosomal subunit.

Frank and colleagues developed a method that allows sorting of particle images into classes based on their orientation, as well as their structural features. Specifically Frank developed mathematical tools used for im…

1987

#13931

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.

In 2007 Capecchi shared the 2007 Nobel Prize in Physiology or Medicine with Martin J. Evans and Oliver Smithies "for their discoveries of principles for introducing specific gene modifications in mice by the use of em…

1987

#13940

Targeted correction of a mutant HPRT gene in mouse embryonic stem cells.

Smithies discovered, simultaneously with Mario Capecchi and Martin Evans, the technique of homologous recombination of transgenic DNA with genomic DNA, a much more reliable method of altering animal genomes than previ…

1990

#14340

Phage antibodies: Filamentous phage displaying antibody variable domains.

Working in the Laboratory of Molecular Biology at Cambridge University, Winter became interested in the idea that all antibodies have the same basic structure, with only small changes making them specific for one targ…

1999

#10053

The black stork: Eugenics and the death of "defective" babies in American medicine and motion pictures since 1915.

2000

#13318

The benefits of medical research and the role of the NIH.

According to Senator Mack's report, the economic costs of illness in the U.S. were approximately $3 trillion annually, representing 31% of the nation’s GDP. This included “direct” costs of public and private health ca…

2002

#8706

Darwin Online. The complete works of Charles Darwin, edited by John van Wyhe.

http://darwin-online.org.uk/AboutUs.html Darwin's Complete Publications Books Origin of Species, Voyage of the Beagle, Descent of Man... Articles Volcanic, Darwin-Wallace paper... Published Letters Life and letters, D…

2002

#12320

Stanford University School of Medicine and the predecessor schools: An historical perspective.

Digital format only, available from lane.stanford.edu at this link: https://lane.stanford.edu/med-history/wilson/chap01.html

2002

#13598

Stem cells and the future of regenerative medicine.

In 2001 this report cited the following diseases with high prevalence in the United States as likely candidates for stem cell research: Cardiovascular Disease: 58 million U.S. patients Automimmune Disease: 30 million …

2003

#14300

Design of a novel globular protein fold with atomic-level accuracy.

Called, "the breakthrough in computational de novo protein design." This was the proof of concept paper that computers and AI could be used to predict protein structures accurately and much faster than with convention…

2006

#13287

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Takahashi and Yamanaka reprogrammed mice fibroblast cells, which can produce only other fibroblast cells, to become pluripotent stem cells, which have the capacity to produce many different types of cells. This they a…

2007

#10346

Encyclopédie sur la mort: La mort et la mort volontaire à travers les pays et les âges.

http://agora.qc.ca/thematiques/mort/

2007

#10466

Morbid Anatomy: Surveying the Interstices of Art and Medicine, Death and Culture.

http://morbidanatomy.blogspot.com/ Events & Talks - Library- Books, Articles, Lectures- Press- Exhibitions- Photography- Bookstore The most comprehensive online reference to these topics curated in a unique manner. In…

2011

#13319

The delivery of regenerative medicines and their impact on healthcare. Edited by Catherine D. Prescott and Dame Julia Polak.

2012

#13925

The educated eye: Visual culture and pedagogy in the life sciences. Edited by Nancy Anderson and Michael R. Dietrich.

2012

#13926

Learning with the lights off: Educational film in the United States. Edited by Devin Orgeron, Marsha Orgeron, Dan Streible.

2013

#13284

The California Institute for Regenerative Medicine. Science, governance, and the pursuit of cures

The California Institute for Regenerative medicine was the first state-fund institution that provided stable, in-state funding on a very large scale for biomedical research. "The California Institute for Regenerative …

2014

#13738

Cancer concepts: A guidebook for the non-oncologist.

https://escholarship.umassmed.edu/cancer_concepts/8/ The first interactive Open access (OA) electronic textbook on any medical subject. This eBook was designed for first year medical students. Order of authorship on t…