EHRLICH, Paul (1854 – 1915)
1854 – 1915
23 entries in the GMN corpus.
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1877
#2487
Beitrag zur Kenntnis der Anilinfärbungen und ihrer Verwendung in der mikroskopischen Technik.
Ehrlich’s first paper on the staining of specific granulation in white blood corpuscles by means of aniline dyes. His work immensely affected subsequent technical methods of staining.
1879
#553.1
Beitrage zur Kenntniss der granulirten Bindegewebszellen und der eosinophilen Leukocyten.
Mast cells; see No. 548.1.
1879 –1880
#880
Methodologische Beiträge zur Physiologie und Pathologie der verschiedenen Formender Leukocyten.
Foundation of the differential blood count technique.
1880
#3125.4
Über Regeneration und Degeneration der rothen Blutscheiben bei Anämien.
1881
#2493
Ueber das Methylenblau und seine klinisch-bakterioskopische Verwerthung.
Introduction of methylene blue in bacteriological staining.
1881
#3125.5
Über einige Beobachtungen am anämischen Blut.
In the above contributions to the knowledge of anemia, Ehrlich dealt in the first paper with the blood cells in anemia, and in the second gave the first description of the reticulocyte.
1885
#2540
Das Sauerstoff-Bedürfniss des Organismus. Eine farbenanalytische Studie.
Includes the first statement of Ehrlich’s “side-chain” theory.
1886
#554
Ueber die Methylenblaureaction der lebenden Nervensubstanz.
Ehrlich’s method of intravital staining.
1888
#3129
Ueber einen Fall von Anämie mit Bemerkungen über regenerative Veränderungen des Knochenmarks.
Ehrlich was first to distinguish the aplastic type of anemia.
1891
#3069.1
Farbenanalytische Untersuchungen zur Histologie und Klinik des Blutes.
Extension of Ehrlich’s work on the differential blood count. By means of his methods of staining blood cells Ehrlich differentiated two types of leukemia, lymphatic and myelogenous.
1891
#5241.1
Ueber die Wirkung des Methylenblau bei Malaria.
Guttmann and Ehrlich demonstrated methylene blue to be lethal in vitro for the malaria parasite – the beginning of Ehrlich’s work on chemotherapy.
1897
#5064
Die Wertbestimmung des Diphtherieheilserums.
Ehrlich improved Behring’s diphtheria antitoxin through quantitative titration and established an international standard for this and other antitoxins. This was the beginning of the concept of biological standardizati…
1900
#14167
The Croonian lecture. -- On immunity with special reference to cell life.
Ehrlich's "lock and key" theory of antibody antigen relationship, or interaction, in which the toxin molecule (i.e the antigen) binds to the cell receptor, and then the antibody binds in a lock and key manner to the t…
1901
#12438
Die Schutzstoffe des Blutes.
In this paper on humoral immunity in humans Ehrlich addressed the bacteriocidal property of the blood, attributing that to antibodies and antitoxins. Digital facsimile from pei.de at this link. (Thanks to Juan Weiss f…
c. 1902
#12437
Ueber die Beziehungen von chemischer Constitution. Vertheilung und pharmakologischer Wirkung: Vortrag, gehalten im Verein für Innere Medicin am 12. December 1898.
In this speech Ehrlich explained how the molecular structure of a drug can define its action and function. It represents his first attempts at modifying the molecular structure of a compound in order to tailor the in …
1904
#2559
Gesammelte Arbeiten über Immunitätsforschung.
Reprints Ehrlich’s writings on immunology to date, as well as three papers by Kyes (Nos. 2111-3). English translation, with two more chapters by Ehrlich and Sachs, and one by Ehrlich, New York, 1906.
1906
#11731
Carl Weigert Gesammelte Abhandlungen unter Mitwirkung von Ludwig Edinger und Paul Ehrlich. Herausgegeben und Eingeleitet von Robert Rieder. 2 vols.
1907
#5281
Chemotherapeutische Trypanosomen-Studien.
The first account of induced microbial drug resistance. Ehrlich encountered induced drug resistance in microbes while researching arsenical preparations as cures for sleeping sickness and other trypanosome-caused illn…
1909
#2565
Beiträge zur experimentellen Pathologie und Chemotherapie.
1910
#2403
Die experimentelle Chemotherapie der Spirillosen (Syphilis, Rückfallfieber, Hühnerspirillose, Frambösie).
After many experiments on the action of synthetic drugs upon spirochetal diseases, Ehrlich and Hata in 1909 discovered Arsphenamine (Salvarsan, "the arsenic that saves", also known as “606”), an effective treatment fo…
1912
#2405
Ueber Laboratoriumsversuche und klinische Erprobung von Heilstoffen.
Introduction of neoarsphenamine (neosalvarsan).
1956 –1960
#86.4
Collected papers of Paul Ehrlich. Compiled and edited by F. Himmelweit. 3 vols.
Vol. I: Histology, biochemistry, and pathology, Vol. 2: Immunology and cancer research; Vol. 3: Chemotherapy. Most texts are in German. English translations are also published when available. The set includes new Engl…
2002
#11417