Facets

1924

#5082

A skin test for susceptibility to scarlet fever.

The “Dick test” for the determination of individual susceptibility to scarlet fever.

1924

#5082.1

The etiology of scarlet fever.

Proof that streptococcus is the cause of scarlet fever.

1925

#5103

Studies on Brucella (Alkaligenes) melitensis.

Forms Bulletin No. 143 of the U.S. Public Health Service Hygienic Laboratory. Alice Evans showed that the causal organism of Malta fever was closely related to Brucella abortus, responsible for contagious abortion in …

1926

#12386

Isolation of a crystalline protein with tuberculin activity.

Siebert identified the active agent in tuberculin as a protein.

1928

#5434.1

Cultivation of vaccinia virus without tissue culture.

Introduction of “Maitland’s medium”.

1931

#4670.5

Immunological differences between strains of poliomyelitis virus.

1931

#2524.1

The susceptibility of the chorio-allantoic membrane of chick embryos to infection with the fowl-pox virus.

By their demonstration of the infection of the chorio-allantoic membrane with the virus of fowl pox, Woodruff and Goodpasture initiated wide-spread adoption of this host for the study of viruses.

1933

#2524.2

A serological differentiation of human and other groups of hemolytic streptococci.

Lancefield determined the principal pathogenic strains of hemolytic streptococci and subdivided them into types. All important strains pathogenic to humans fall into Lancefield’s Group A.

1934

#12387

The isolation and properties of the purified protein derivative of tuberculin

Purification of tuberculin (PPD). By the 1940s Seibert's PPD was the international standard for tuberculin tests.

1935

#2524.4

The natural occurrence of pleuropneumonia-like organisms in apparent symbiosis with Streptobacillus moniliformis and other bacteria.

Klieneberger isolated typical strains of pleuropneumonia-like organisms from Strep, moniliformis.

1935

#2576.3

A protective action of neurotropic against viscerotropic yellow fever virus in Macacus rhesus.

One of the first examples of an animal virus interference phenomenon was demonstrated by Hoskins.

1936

#5484.2

Propagation of rabies virus in tissue culture and the successful use of culture virus as antirabic vaccine.

Webster and Clow succeeded in growing rabies virus in tissue culture.

1937

#5398

Experimental studies on the virus of “Q” fever.

Discovery of Rickettsia burneti, causal agent in Q fever.

1938

#4660

Recovery of the virus of equine encephalomyelitis from the brain of a child.

Western equine encephalitis virus recovered from man.

1938

#2576.7

Recherches sur le phénomène de Twort-d’Hérelle (bactériophage ou autolyse hérédo-contagieuse).

The Wollmans made important contributions to the knowledge on bacteriophage and lysogeny.

1939

#2525

The anaerobic bacteria and their activities in nature and disease. A subject bibliography. 2 vols.

Supplements were published: 1938-1975, 8 vols., 1941-82.

1940

#5259

Klinische und parasitologische Befunde und chemotherapeutische Ergebnisse bei der Hühnermalaria.

Discovery of the developmental forms of P. gallinaceum in the incubation period.

1941

#2578

The absorption of influenza virus by red cells and a new in vitro method of measuring antibodies for influenza virus.

Independently of Hirst, McClelland and Hare discovered virus hemagglutination.

1948

#5545

An unidentified, filterable agent isolated from the feces of children with paralysis.

Isolation of the Coxsackie virus from the stool of a patient residing in Coxsackie, New York.

1949

#5515

Pure granulomatous nocardiosis: a new fungus disease distinguished by intracellular parasitism. A description of a new disease in man due to a hitherto undescribed organism, Nocardia intracellularis, n.sp., including a study of the biological and pathogenic properties of this species.

Nocardiosis described.

1952

#256

Independent functions of viral protein and nucleic acid in growth of bacteriophage.

DNA shown to be the carrier of genetic information in virus reproduction. In 1969 Hershey shared the Nobel Prize in Physiology or Medicine with S. E. Luria and M. Delbrück for "for their discoveries concerning the rep…

1955

#5546.3

Propagation and primary isolation of mumps virus in tissue culture.

1956

#2527.2

Propagation in tissue culture of a cytopathogenic virus from human salivary gland virus (SGV) disease.

Isolation of cytomegalovirus

1957

#2660.10

The induction of neoplasms with a substance released from mouse tumors by tissue culture.

Isolation of polymavirus (papovavirus). With B. E. Eddy, A. M. Gochenour, N. G. Borgese, and G E. Grubbs.

1960

#2660.13

Virus-cell interaction with a tumour-producing virus.

Polyomavirus (papovavirus) shown to be capable of transforming cells in culture. Full text from PubMedCentral at this link.

1962

#10920

Powassan virus: Field investigations in Northern Ontario, 1959-1961.

The authors isolated a virus from the brain of a child who died of encephalitis in Powassan, Ontario, and named it the Powassan virus. They posited a tick vector and possible rodent natural hosts. (Thanks to Juan Weis…

1964

#2660.17

Cultivation in vitro of human lymphoblasts from Burkitt’s malignant lymphoma.

Order of authorship in the original publication: Epstein, Barr. Discovery of the Epstein-Barr virus, a human herpes virus causing infectious mononucleosis, and implicated in Burkitt’s lymphoma and other forms of cance…

1964

#2660.18

Virus particles in cultured lymphoblasts from Burkitt’s lymphoma.

Order of authorship in the original publication: Epstein, Achong, Barr. Presence of herpes-like virus particles in Burkitt’s tumor cells reported. The Epstein-Barr virus was the first human cancer-causing virus to be …

1967

#12834

Does the agent of scrapie replicate without nucleic acids?

This paper, which predated Griffith's' paper (No. 12833), demonstrated that the scrapie agent replicates without nucleic acids. Alper and colleagues irradiated scrapie infected mouse brain extracts with lethal ultravi…

1968

#5487.1

Relation of Burkitt’s tumor-associated herpes-type virus to infectious mononucleosis.

The Henles and Diehl showed that Epstein-Barr virus is the aetiological agent in infectious mononucleosis.

1975

#11190

Parvovirus-like particles in human sera. Preliminary communication.

Order of authorship in the original paper: Cossart, Field, Cant. First description of Parvovirus B19, the first human parvovirus discovered. It is among the smallest DNA viruses and is most often known for causing dis…

1976

#11104

Deoxyribonucleic acid polymerase from the extreme thermophile Thermus aquaticus.

The authors showed that the heat resistant bacteria Thermus aquaticus discovered by Thomas Brock contained a vital polymerase enzyme that had evolved in this bacteria to allow it to metabolize and survive in exception…

1977

#10923

Isolation and partial characterization of a new virus causing acute haemorrhagic fever in Zaire.

The first of three papers published in Lancet back to back describing the discovery of Ebola Virus Disease. In this paper the authors described isolation of the virus, imaged it with an electron microscope, and named …

1977

#11043

An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA.

Discovery of introns. In 1993 Roberts shared the Nobel Prize in Physiology or Medicine with Phillip A. Sharp "for their discoveries of split genes." It was frequently suggested that Chow deserved a share of that prize…

1977

#11044

Spliced segments at the 5' terminus of adenovirus 2 late mRNA.

Discovery of introns simultaneously with Roberts, Chow, Broker (No. 11043). Sharp's electron microscopist, Berget, visualized the introns in the electron microscope. James D. Watson took note of the profound significa…

1983

#6996

Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).

Isolation of the human immunodeficiency virus (HIV-1). In 2008 Barré-Sinoussi and Montagnier shared half of the Nobel Prize in Physiology and Medicine "for their discovery of human immunodeficiency virus." The other h…

1983

#11191

Human parvovirus, the cause of erythema infectiosum (Fifth disease)?

This single page document was published as a Letter to the Editor of The Lancet. Order of authorship of the letter: Anderson, Jones, Fisher-Hoch.... Identification of human parvovirus as the cause of "Fifth disease". …

1984

#11059

A new type of retrovirus isolated from patients presenting with lymphadenopathy and acquired immune deficiency syndrome: Structural and antigenic relatedness with equine infectious anemia virus.

Order of authorship in the original publication: Montagnier, Dauguet,... Barré-Sinoussi. In this paper Montagnier and colleagues showed that, contrary to the views of Gallo and his group, LAV (Lymphadenopathy Associat…

1985

#11377

The association between idiopathic hemolytic uremic syndrome and infection by Verotoxin-producing Escherichia coli.

Order of authorship in the original publication: Karmali, Petric, Lim. The authors discovered that a hemolytic uremic syndrome, associated with E. coli 0157-H7 (first described in No. 11376), and which could not be cu…

1986

#10788

Isolation of a new human retrovirus from West African patients with AIDS.

HIV-2 was discovered essentially simultaneously by French and U.S. teams. This was the first publication by the French team. Order of authorship of the original publication was Clavel, Guettard, Brun-Vezinet. See thei…

1987

#11192

Human parvovirus infection in pregnancy and hydrops fetalis.

Demonstration of the devastating effect of human parvovirus B19 on the human fetus. (Thanks to Juan Weiss for this reference and its interpretation.)

1987

#11246

DF-2 bacteremia following cat bites. Report of two cases.

Order of authorship in the original paper: Carpenter, Heppner, Gnann. Report of two cases of infection from cat bites by the bacterium then identified by the CDC as DF-2 (later called Capnocytophaga canimorsus) in non…

1995

#10914

Kaposi's Sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas.

Chang, Moore and colleagues showed that the virus causing Kaposi's Sarcoma also causes body cavity lymphomas and lymphomatous effusions in humans. (Thanks to Juan Weiss for this reference and its interpretation.)

1998

#10900

Ehrlichia chaffeensis in Missouri ticks.

Order of authorship in the original paper: Roland, Everett, Cyr. Using PCR, the authors demonstrated that the tick Amblyoma americanum (the Lone Star Tick) was the insect vector of Ehrlichia chaffeensis. Digital facsi…

1998

#11342

Complete genome sequence of treponema pallidum, the syphilis spirochete.

Order of authorship in the original publication: Fraser, Norris, Weinstock....Smith, Venter. Sequence of the genome of the bacterium that causes syphilis. (Thanks to Juan Weiss for this reference and its interpretation.)

2002

#11336

Genome sequence of the human malaria parasite Plasmodium falciparum.

Order of authorship in the original paper: Gardner, Hall, Fung.... Genome of the Plasmodium falciparum parasite carried by the mosquito that causes malaria in humans. (Thanks to Juan Weiss for this reference and its i…

2003

#11347

The invisible enemy: A natural history of viruses.

2005

#11193

Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: A double blind randomized placebo-controlled trial.

Order of authorship in the original paper: Taylor, Makunde, McGarry.... The authors treated infection by the parasitic worm Wuchereria bancrofti, cause of elephantiasis (lymphatic filariasis), by killing the Wolbachia…

2005

#11335

Characterization of the reconstructed 1918 Spanish Influenza Pandemic virus.

Order of authorship in the original publication: Tumpey, Basler, Aguilar... Taubenberger. Reconstruction of the genome of the 1918 Spanish Influenza virus from frozen tissue samples from a mass grave of victims of the…

2005

#11339

The genome of the African trypanosome Trypanosoma brucei.

Genome of the parasite that causes Sleeping Sickness. (Thanks to Juan Weiss for this reference and its interpretation.)