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Garrison-Morton-Norman History of Medicine

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Drugs & Technology

33 entries match Oncology & Cancer [C04] · Pharmacology & Therapeutics [D01 / E02]

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1761

#2607.1

Cautions against the immoderate use of snuff. Founded on the known qualities of the tobacco Plant; and the effects it must produce when this way taken Into the body: And by instances of persons who have perished miserably of diseases, occasioned, or rendered incurable by its use,

HILL, (Sir) John (1714 – 1775)
HILL, (Sir) John (1714 – 1775)

First clinical report (pp. 30-31) of an association between tobacco and cancer, in this case “polypusses” of the nose caused by taking snuff. Hill was a distinguished botanist and apothecary, although regarded by some…

1795

#2609.1

De morbis vasorum absorbentium corporis humani.

SOEMMERRING, Samuel Thomas von (1755 – 1830)

Soemmerring noted an association between pipe smoking and cancer of the lip (p. 109).

1820

#2073

Pharmacologia; or the history of medicinal substances, with a view to establish the art of prescribing. 3rd ed.

PARIS, John Ayrton (1785 – 1856)
PARIS, John Ayrton (1785 – 1856)

First description of cancer caused by arsenic (p. 133).

1867

#1996.3

On the electrolytic treatment of tumors, and other surgical diseases.

ALTHAUS, Julius (1833 – 1900)
ALTHAUS, Julius (1833 – 1900)

Althaus introduced Duchenne’s methods into England. He was the first to employ electrolysis for medical purposes. Greatly expanded third edition, 1873.

1898

#2003

Sur une substance nouvelle radio-active, contenue dans la pechblende.

CURIE, Pierre (1859 – 1906)
CURIE, Pierre (1859 – 1906)
CURIE, Marie Sklodowska (1867 – 1934)
CURIE, Marie Sklodowska (1867 – 1934)

The Curies, studying the radioactivity of minerals containing uranium and thorium, isolated from pitchblend a substance which they called radium and which they showed to possess an astonishing degree of radioactivity.…

1906

#2005

Interprétation de quelques résultats de la radiothérapie et essai de fixation d’une technique rationelle.

BERGONIÉ, Jean (1857 – 1925) TRIBONDEAU, Louis Mathieu Frédéric Adrien (1872 – 1918)

Bergonié-Tribondeau law, “the sensitivity of cells to radiation varies directly with the reproductive capacity of the cells and inversely with their degree of differentiation” (Dorland).

1916

#2643

Ueber die künstliche Erzeugung von Karzinom.

YAMAGIWA, Katsusaburo (1863 – 1930) ICHIKAWA, Koichi (1888 – 1948)

First experimental production of tar cancer in rabbits by painting with tar products. This was the first proof of chemical carcinogenesis.

1924

#2646

The formation of a cancer-producing substance from isoprene (2-methyl-butadiene).

KENNAWAY, Sir Ernest Laurence (1881 – 1958)
KENNAWAY, Sir Ernest Laurence (1881 – 1958)

Kennaway produced carcinogenic tars by submitting acetylene or isoprene to high temperatures in an atmosphere of hydrogen, thus proving that some carcinogens are pure hydrocarbons.

1932 –1934

#1921

Handbuch der Chemotherapie. 2 vols.

FISCHL, Viktor SCHLOSSBERGER, Hans (1887 – 1960)

1932

#2654

The production of cancer by pure hydrocarbons.

COOK, Sir James Wilfred (1900 – 1975)
COOK, Sir James Wilfred (1900 – 1975)

Discovery of the carcinogenic properties of dibenzanthracene compounds. With I. Hieger, E. L. Kennaway, and W. V. Mayneord.

1939

#3213

Tabakmissbrauch und Lungencarcinom.

MÜLLER, Franz Hermann

In the first case-control epidemiological study of the effects of tobacco Müller recorded a statistically significant correlation between cigarette smoking and lung cancer. See Alfredo Morabia, "Quality, originality, …

1944

#2659.3

Influence of synthetic oestrogens upon advanced malignant disease.

HADDOW, Sir Alexander (1907 – 1976)
HADDOW, Sir Alexander (1907 – 1976) & et al.

Administration of synthetic estrogens in advanced mammary cancer caused regression of tumors. With J. M. Watkinson, E. Paterson, and P. C. Koller.

1946

#10133

Nitrogen mustard therapy. Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders.

GOODMAN, Louis Sanford (1906 – 2000)
GOODMAN, Louis Sanford (1906 – 2000)
GILMAN, Alfred Zack (1908 – 1984)
GILMAN, Alfred Zack (1908 – 1984) WINTROBE, Maxwell Myer (1901 – 1986) DAMESHEK, William (1900 – 1969)

Widely considered the first uses of chemotherapy for the treatment of malignant diseases.

1948

#2660.1

Temporary remissions in acute leukemia in children produced by folic acid antagonist 4-amethopteroylglutamic acid (aminopterin).

FARBER, Sidney (1903 – 1973)
FARBER, Sidney (1903 – 1973)

With L. K. Diamond, R. D. Mercer, R. F. Sylvester, and V. A. Wolff.

1950

#3215.1

Tobacco smoking as a possible etiologic factor in bronchogenic carcinoma: A study of 684 proved cases.

GRAHAM, Evarts Ambrose (1883 – 1957)
GRAHAM, Evarts Ambrose (1883 – 1957) WYNDER, Ernst Ludwig (1922 – 1999)

A case-control study proving an association between heavy prolonged cigarette smoking and bronchogenic carcinoma. See also the following paper on pp. 336-38. Reprinted in J. Amer. med. Assoc. 1985, 253, 2986-97.

1950

#3215.2

Smoking and carcinoma of the lung. Preliminary report.

DOLL, Sir William Richard Shaboe (1912 – 2005)
HILL, Sir Austin Bradford (1897 – 1999)
HILL, Sir Austin Bradford (1897 – 1999)

A study of 1,465 cases of lung cancer and 1,465 matched controls, which confirmed and extended the studies of Wynder and Graham, and others. See also later papers by the same authors in Brit. med. J., 1952, 2,1271-86;…

1952

#7764

Incidence of leukemia in survivors of the atom bomb in Hiroshima and Nagasaki, Japan.

FOLLEY, J. H. BORGES, T. YAMASAKI, T.

Leukemia was the first cancer to be linked with radiation exposure in atomic bomb survivors.

1953

#2660.4

Aryl-2-halogenoalkylamines. Part XII. Some carboxylic derivatives of NN-Di 2-chloroethylaniline.

EVERETT, James Lionel

Chlorambucil (a nitrogen mustard) used in the chemotherapy of cancer. With J. R. Roberts and W. J. C. Ross.

1954

#2660.7

Cytoactive amino-acid and peptide derivatives. I. Substituted phenylalanines.

BERGEL, Franz (1900 – 1987) STOCK, J. A.

Melphalan (a nitrogen mustard) later used in the chemotherapy of cancer.

1955

#2660.8

Carcinolytic action of antibiotics: puromycin and actinomycin.

FARBER, Sidney (1903 – 1973)
FARBER, Sidney (1903 – 1973)

1956

#1947.3

Mitomycin, a new antibiotic from streptomyces.

HATA, Toju (1908 – 2004) & et al.

Isolation of mitomycin C, effective in Hodgkin’s disease and lymphoma. With six co-authors.

1956

#7782

Preliminary communication: Malignant disease in childhood and diagnostic irradiation in-utero.

STEWART, Alice Mary (1906 – 2002)
STEWART, Alice Mary (1906 – 2002) & et al.

Stewart was one of the earliest to study the effect of prenatal X-rays, later replaced by ultrasound. She found that the children of mothers who received these X-rays were almost twice as likely to develop leukemia or…

1958

#2660.11

Neuartige Krebs-Chemotherapeutica aus der Gruppe der zyklischen N-Lost-Phosphamidester.

ARNOLD, Herbert & et al.

Cyclophosphamide. With F. Bourseaux and N. Brock.

1963

#2660.14

Evidence that the L-asparaginase of guinea pig serum is responsible for its antilymphoma effects.

BROOME, John Denis

1963

#2660.16

The Vinca alkaloids: a new class of oncolytic agents.

JOHNSON, Irving Stanley (1925 – 2014) & et al.

Clinical use of vinblastine (for Hodgkin’s disease and other lymphomas) and vincristine (for acute leukemias of childhood). With J. G. Armstrong, M. Gorman, and J. P. Burnett. Preliminary communication in J. Lab. clin…

1964

#7385

Smoking and health: report of the Advisory Committee to the Surgeon General of the Public Health Service.

U.S. PUBLIC HEALTH SERVICE
TERRY, Luther (1911 – 1985)
TERRY, Luther (1911 – 1985)

Definitive 386-page throughly documented study of the carcinogenic and pulmonologic effects of smoking, and the addictive aspects of nicotine. It was published under the supervision of Surgeon-General Luther Terry. Di…

1965

#7790

Mortality from cancer and other causes after radiotherapy for ankylosing spondylitis.

DOLL, Sir William Richard Shaboe (1912 – 2005) BROWN, William Michael Court (1918 – 1968)

1970

#2660.24

Combination chemotherapy in the treatment of advanced Hodgkin’s disease.

DE VITA, Vincent Theodore Jr. (1935 – ) & et al.

Combination chemotherapy with nitrogen mustard (mustine hydrochloride), vincristine sulphate, procarbazine hydrochloride and prednisone, introduced in 1964 for the treatment of advanced Hodgkin’s disease. With A. A. S…

1970

#7761

Low dose radiation and cancer.

GOFMAN, John William (1918 – 2007)
GOFMAN, John William (1918 – 2007) TAMPLIN, Arthur R.

This paper, delivered at the 1969 Nuclear Science Symposium and Nuclear Power Systems Engineering Symposium, October, 1969, provided powerful scientific evidence that the then currently allowable radiation dose (Feder…

1970

#7783

Radiation dose effects in relation to obstetric X-rays and childhood cancers.

STEWART, Alice Mary (1906 – 2002)
STEWART, Alice Mary (1906 – 2002) KNEALE, George W.

In this study of ten million children Stewart and Kneale showed that obstetric X-rays significantly increased the rate of childhood leukemia and cancer.

1981

#7760

Radiation and human health.

GOFMAN, John William (1918 – 2007)
GOFMAN, John William (1918 – 2007)

The first comprehensive book summarizing the evidence relating low-level ionizing radiation to cancer and other diseases.

1991

#8650

Milestones in leukemia research and therapy.

FREIREICH, Emil J. (1927 – ) LEMAK, Noreen Ann (1921 – 2013)

Freireich was part of the team that first introduced combined-drug cancer chemotherapy in 1965.

1999

#10229

The Nazi war on cancer.

PROCTOR, Robert N. (1954 – )
PROCTOR, Robert N. (1954 – )