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LEACH, D. R.

1 entries in the GMN corpus.

1996

#14267

Enhancement of antitumor immunity by CTLA-4 blockade.

In the early 1990s James Allison showed that CTLA-4 acts as an inhibitory molecule to restrict T-cell responses. In 1996, Allison was the first to show that antibody blockade of a T-cell inhibitory molecule (known as …