1930 TISELIUS, Arne Wilhelm Kaurin (1902 – 1971)

The moving boundary method of studying the electrophoresis of proteins. (Nova Acta Reg. Soc. Scient. Upsaliensis, IV, 7, No. 4.)

Tilesius's doctoral dissertation introduced the laboratory technique of moving-boundary electrophoresis, a technique for separation of chemical compounds by electrophoresis in free solution. For this work, and the wor…

GMN 12830 · https://beta.historyofmedicine.com/id/15076

1935 ZERNIKE, Frits (1888 – 1966)

Das Phasenkontrastverfahren b.d. mikroskopischen Beobachtung.

Zernicke invented phase contrast microscopy. In 1953 Zernike was awarded the Nobel Prize in Physics "for his demonstration of the phase contrast method, especially for his invention of the phase contrast microscope."

GMN 269.5 · https://beta.historyofmedicine.com/id/8750

1975 HENDERSON, Richard (1945 – ); UNWIN, Peter Nigel Tripp

Three-dimensional model of purple membrane obtained by electron microscopy.

The invention of Cryogenic electron microscopy (cryo-EM). The novel technique was achieved by "by applying the method to tilted specimens, and using the principles put forward by De Rosier and Klug (GM - 13935), for t…

GMN 14182 · https://beta.historyofmedicine.com/id/16497

1981 FRANK, Joachim (1940 – ); VERSCHOOR, Adriana; BOUBLIK, Miloslav (1929 – 1994)

Computer averaging of electron micrographs of the 405 ribosomal subunit.

Frank and colleagues developed a method that allows sorting of particle images into classes based on their orientation, as well as their structural features. Specifically Frank developed mathematical tools used for im…

GMN 14183 · https://beta.historyofmedicine.com/id/16498