Nova et tuta variolas excitandi per transplantationem methodus; nuper inventa & in usum tracta: Qua rite peracta, immunia in posterum praeservantur ab huiusmodi contagio corpora.

Inoculation was practiced in ancient times. In 1701 Pilarino inoculated three children at Constantinople with smallpox virus. He is credited with the “medical” discovery of variolation, and is thus the first immunologist. His book records his many researches on the subject.