Observations on the composition of glomerular urine with particular reference to the problem of reabsorption in the renal tubules.

Experimental proof that the initial step in urine production is the formation in Bowman’s space of a protein-free ultrafiltrate of plasma and that reabsorption of certain substances must occur in the tubules since they were present in the filtrate but absent from the final urine. One of the most significant of all publications in renal physiology.