Historical Bibliography Updated: July 14, 2026
CYCLE Is a Second bHLH-PAS Clock Protein Essential for Circadian Rhythmicity and Transcription of Drosophila period and timeless.
Cell, 93, 805-814. 1998.
In 1998 Rosbach, Hall and colleagues discovered the cycle gene, clock gene, and cryptochrome photoreceptor in Drosophila through the use of forward genetics, by first identifying the phenotype of a mutant and then determining the genetics behind the mutation.
Order of authorship in the original publication: Rutila, Suri, Le, So, Rosbash, Hall. Digital text from cell.com at this link.
See also: Stanewsky, R.; Kaneko, M.; Emery, P.; Beretta, B.; Wager-Smith, K.; Kay, S.A.; Rosash, M.; Hall, J. C., "The cryb Mutation Identifies Cryptochrome as a Circadian Photoreceptor in Drosophila," Cell, 95, 1998, 681-682.
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| Catalog Metadata | Reference Information |
|---|---|
| Entry Number | #14264 |
| Permanent Link | https://beta.historyofmedicine.com/id/16585 |
| Author Bio Link | Wikipedia ↗ |
| External URL | cycle-is-a-second-bhlhpas-clock-protein-essential-for-circadian-rhythmicity-and-transcription-of-drosophila-period-and-timeless |