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Historical Bibliography Updated: July 14, 2026

CYCLE Is a Second bHLH-PAS Clock Protein Essential for Circadian Rhythmicity and Transcription of Drosophila period and timeless.

Cell, 93, 805-814. 1998.

In 1998 Rosbach, Hall and colleagues discovered the cycle gene, clock gene, and cryptochrome photoreceptor in Drosophila through the use of forward genetics, by first identifying the phenotype of a mutant and then determining the genetics behind the mutation. 
Order of authorship in the original publication: Rutila, Suri, Le, So, Rosbash, Hall. Digital text from cell.com at this link.

See also: Stanewsky, R.; Kaneko, M.; Emery, P.; Beretta, B.; Wager-Smith, K.; Kay, S.A.; Rosash, M.; Hall, J. C.,  "The cryb Mutation Identifies Cryptochrome as a Circadian Photoreceptor in Drosophila," Cell, 95, 1998, 681-682.

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Entry Number#14264
Permanent Linkhttps://beta.historyofmedicine.com/id/16585
Author Bio LinkWikipedia ↗
External URLcycle-is-a-second-bhlhpas-clock-protein-essential-for-circadian-rhythmicity-and-transcription-of-drosophila-period-and-timeless