1652 TULP, Nicolaes (1593 – 1674)

Observationes medicae.

One of the earliest accounts of beri-beri is on pp. 300-05 of this work. Tulp, notable as the demonstrator in Rembrandt’s “Anatomy Lesson”, was among the first, in the same book, to describe the ileo-caecal valve (“Tu…

GMN 3737 · https://beta.historyofmedicine.com/id/4530

1914 BOVERI, Theodor (1862 – 1915)

Zur Frage der Entstehung maligner Tumoren.

Boveri argued that malignancy arises as a consequence of chromosomal abnormalities, and that multiplication is an inherent property of cells. He predicted the existence of tumor suppressor mechanisms and was perhaps t…

GMN 7759 · https://beta.historyofmedicine.com/id/9931

1952 GEY, George Otto (1899 – 1970); COFFMAN, Ward D.; KUBICEK, Mary T.; LACKS, Henrietta (1920 – 1951)

Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium.

A cell biologist at Johns Hopkins Hospital, Gey propagated the HeLa cell line from Henrietta Lacks' cervical tumor. This cell line, which maintained a continuous growth phase, was the first immortal human cell line to…

GMN 14100 · https://beta.historyofmedicine.com/id/16411

1970 BALTIMORE, David (1938 – )

Viral RNA-dependent DNA polymerase: RNA-dependent DNA polymerase in virions of RNA tumour viruses.

In 1970 Baltimore and Temin discovered that certain viruses that have their genes in the form of RNA can copy the RNA "backward" into DNA in infected cells. The enyzme, reverse transcriptase, enables the manufacture o…

GMN 2660.22 · https://beta.historyofmedicine.com/id/3429

1970 TEMIN, Howard Martin (1934 – 1994); MIZUTANI, Satoshi

RNA-dependent DNA polymerase in virions of Rous sarcoma virus.

Discovery of reverse transcriptase. "In 1969, Temin and a postdoctoral fellow, Satoshi Mizutani, began searching for the enzyme that was responsible for the phenomenon of viral RNA being transferred into proviral DNA.…

GMN 2660.23 · https://beta.historyofmedicine.com/id/3432

1975 DULBECCO, Renato (1914 – 2012)

From the molecular biology of oncogenic DNA viruses to cancer. Les Prix Nobel en 1975, pp. 172-80.

In 1975 Dulbecco shared the Nobel Prize in Physiology or Medicine with David Baltimore and Howard Martin Temin "for their discoveries concerning the interaction between tumour viruses and the genetic material of the c…

GMN 2660.27 · https://beta.historyofmedicine.com/id/3440

1976 VARMUS, Harold Eliot (1942 – ); BISHOP, John Michael (1936 – ); STEHELIN, Dominique (1943 – 2019); VOGT, Peter K. (1932 – )

DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA.

Discovery of the first “oncogene. In 1989 Varmus and Bishop shared the Nobel Prize for in Physiology or Medicine "for their discovery of the cellular origin of retroviral oncogenes."

GMN 2660.28 · https://beta.historyofmedicine.com/id/3441

1979 LEVINE, Arnold Jay (1939 – ); LINZER, Daniel I. H. (1954 – )

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40 transformed cells and uninfected embryonal carcinoma cells.

Levine discovered the tumor suppressor protein p53, also known as Tumor protein P53. Because it prevents cancer formation TP 53 is classified as a tumor suppressor gene. The discovery was completed in 1989 and recorde…

GMN 14007 · https://beta.historyofmedicine.com/id/16312

2006 FIES, Brian

Mom's cancer.

This book was born digital in 2004, and later published in print. See www.momscancer.com. "Winner of the 2005 Eisner Award in the category of Best Digital Comic for the original Web version" "Brian Fies is a freelance…

GMN 9820 · https://beta.historyofmedicine.com/id/12008

2013 ADEY, Andrew C.; BURTON, Joshua N.; KLITZMAN, Jacob O.; ET AL

The haplotype-resolved genome and epigenome of the aneuploidy HeLa cancer cell line.

Adey and colleagues sequenced the haplotype-resolved whole genome of the HeLa cancer cell line. This showed a highly rearranged region at chromosome 8q24.21, where an integration locus of the HPV (human papillomavirus…

GMN 14101 · https://beta.historyofmedicine.com/id/16412